ArticleResearch square2026
Holotomography-Based, Label-Free Quantification of Cellular Dry Mass as a Biophysical Indicator of Microglial Aβ Phagocytosis during Senescence.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Senescent microglia undergo significant molecular and biochemical changes associated with impaired phagocytosis of amyloid-β (Aβ), a process implicated in neurodegenerative disease progression. However, quantitative biophysical metrics capable of capturing this functional impairment-and thus elucidating the role of microglial dysfunction in disease progression-remain limited. In this study, we identify cellular dry mass, measured by label-free holotomography, in combination with cell and nuclear morphological features, as sensitive biophysical indicators of microglial senescence and phagocytic capacity. Microglial senescence was induced using optimized hydrogen peroxide (H
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