Evidence map›Paper›PMID 41674817›Full record

ArticleResearch square2026

Endosome maturation is orchestrated by inside-out proton signaling through a Na

YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

YouJin LeeDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.ORCID 0000-0003-0670-4255
Qing OuyangDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.
Li MaDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.
Morgan FleishmanDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.
Hasib Aamir RiazDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.
Michael SchmidtDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.ORCID 0000-0002-7990-033X
Jeffrey L DupreeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA, 23284.
Anupam MondalArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA, 77843.ORCID 0000-0002-8436-5618
Priyesh MohantyArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA, 77843.
Jeetain MittalArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA, 77843.ORCID 0000-0002-9725-6402
Oliver BecksteinDepartment of Physics, Arizona State University, Tempe, AZ, USA, 85287.ORCID 0000-0003-1340-0831
David G LambrightProgram in Molecular Medicine and Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA, 01605.
Eric M MorrowDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA, 02912.ORCID 0000-0003-3430-3520

Funding

Pathogenic Mechanisms in Christianson Syndrome and NHE6-Related DisordersR01NS113141 · NINDS · BROWN UNIVERSITY · PI Eric M Morrow · 2019 to 2026
$7.0M
Mechanisms of Disease and Treatments in Novel Metabolic Development Brain DisordersR01NS121618 · NINDS · BROWN UNIVERSITY · PI Eric M Morrow · 2022 to 2026
$3.2M
Neurodevelopmental mechanisms in 17q12 CNV disorders and autismR01MH137004 · NIMH · BROWN UNIVERSITY · PI Eric M Morrow · 2024 to 2026
$2.4M
Metabolic Mechanisms in Locus Coeruleus Neuron Vulnerability in Neurodegenerative DiseaseR01AG087455 · NIA · BROWN UNIVERSITY · PI Eric M Morrow · 2024 to 2026
$2.3M
Multiscale Computational Models to Investigate the Role of Phase Separation in BiologyR35GM153388 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jeetain Mittal · 2024 to 2026
$1.3M
NHE6-mediated endosomal defects in neurodegenerative disordersK99AG076868 · NIA · BROWN UNIVERSITY · PI LEE, EUGENE Y · 2023 to 2024
$239k
NIA NIH HHS K99 AG076868NIA NIH HHS R01 AG087455NIGMS NIH HHS R35 GM153388NIMH NIH HHS R01 MH137004NINDS NIH HHS R01 NS113141NINDS NIH HHS R01 NS121618
6 · The paper itself

Abstract

Endosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na

Identifiers

PMID41674817
PMCPMC12889811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.