Evidence map›Paper›PMID 41674814›Full record

ArticleResearch square2026

Pericentromeric Transcription of Novel Pathogen-Related Human GPS Genes in Cancers is Regulated by C19MC miRNAs, CEBPB, IFN-γ, and IFN-β.

Goodwin Jinesh, Isha Godwin, Marco Napoli, Elsa Flores, Andrew Brohl

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Goodwin JineshMoffitt Cancer Center.ORCID https://orcid.org/0000-0002-2170-3245
Isha Godwin
Marco Napoli
Elsa Flores
Andrew Brohl

Funding

Role of the Chromosome 19 MicroRNA Cluster in Liver CancersK08CA255933 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BROHL, ANDREW SCOTT · 2021 to 2023
$746k
NCI NIH HHS K08 CA255933
6 · The paper itself

Abstract

Pericentromeric transcription is unique to testis, and oocytes among the normal tissues. However, its regulation in cancer is not well-understood. Here, we discover a novel human, intron-less, coding, pericentromeric GPS gene family in cancer cells, with protein-level homology to microbial proteins from

Indexed as

C17GPSC19MCC6GPSCEBPB-LAPGPS: Genes at Pericentromeric-repeat SequencesIFN-βIFN-γMiniopterus natalensismiR-519DmiR-520GmiR-526BNonsense-mediated decay (NMD)Pericentromeric transcriptionPlasmodium ovale wallikeriSalmonella entericaStaphylococcus hominisStreptococcus pneumoniaeStreptomyces sp.Vibrio vulnificus

Identifiers

PMID41674814
PMCPMC12889837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.