ArticlemedRxiv : the preprint server for health sciences2026
Estimating enteric fever seroincidence in rural western Cambodia: findings from a population-based cross-sectional serosurvey.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Enteric fever, caused by Methods: Samples from a representative cross-sectional household serosurvey in rural western Cambodia were used to estimate enteric fever seroincidence among children and young adults. Participants were enrolled between April 7 and December 10, 2023, and 529 samples from individuals aged 5-25 years were analysed. Using IgA and IgG responses to hemolysin E antigen and established models of antibody decay after infection, we estimated seroincidence, conveying the rate of new infection in the population. Participants were enrolled between April and December 2023, and 529 samples from individuals aged 5-25 years were analysed. Results: The overall enteric fever seroincidence rate was 161.8/1,000 person-years (95%CI: 144.6, 181.0). Among children 5-15 years, it ranged between 149.5 (95%CI: 128.7, 173.7) and 239.0 (95%CI:169.2, 337.6) across districts. Seroincidence was numerically higher among children 5-15 years from households with unimproved drinking water sources or sanitation facilities, and districts with a higher proportion of households with unimproved WASH. Conclusion: These findings potentially support the introduction of the typhoid conjugate vaccine in rural western Cambodia. However, additional data on the relative contribution of
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