Evidence map›Paper›PMID 41674644›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Critical and non-critical connections not differently associated with either Alzheimer's disease or vascular pathologies.

Naomi Vlegels, Bruno M de Brito Robalo, Alberto de Luca, Wiesje M van der Flier, Dominantly Inherited Alzheimer Network (DIAN), Randall Bateman, Tammie L S Benzinger, Carlos Cruchaga, Dave M Cash, Hiroshi Mori and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Naomi VlegelsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Bruno M de Brito RobaloDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Alberto de LucaDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Wiesje M van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Dominantly Inherited Alzheimer Network (DIAN)
Randall BatemanDepartment of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Tammie L S BenzingerMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Dave M CashDementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
Hiroshi MoriDepartment of Clinical Neuroscience, Medical School, Osaka Metropolitan University, Nagaoka Sutoku University, Abenoku, Osaka, Nagaoka, Japan.
Igor YakushevDepartment of Nuclear Medicine, Technical University of Munich, Munich, Germany.
Marco DueringInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany.
Sofia FinsterwalderInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany.
Benno GesierichInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany.
Anna KopczakInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany.
Yael D ReijmerDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Geert Jan BiesselsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

Imaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9M
NIA NIH HHS U19 AG032438
6 · The paper itself

Abstract

Following observations from a pilot study that, contrary to expectations, indicated that critical white matter (WM) connections were not more vulnerable to either SVD or AD pathologies than non-critical connections, we set out to systematically evaluate the relation between these pathologies and both connections types. For patients with CADASIL (n=59), Mixed pathology (n=57) and autosomal dominant AD (ADAD; n=50) we reconstructed WM networks based on diffusion tensor imaging and subsequently defined critical and non-critical connections. Associations between AD markers (CSF Aβ

Indexed as

CADASILcerebral small vessel diseasediffusion magnetic resonance imagingfamilial Alzheimer’s diseasestructural brain networkwhite matter

Identifiers

PMID41674644
PMCPMC12889768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.