ArticlemedRxiv : the preprint server for health sciences2026
Disentangling Environmental and Genetic Influences on Associations Between Childhood Bullying Victimization and Psychotic-Like Experiences.
Nicole R Karcher, Deanna M Barch, Hans Oh, Sarah E Paul, K Juston Osborne, David Aa Baranger, Ryan Bogdan, Arpana Agrawal, Emma C Johnson
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Nicole R KarcherDepartment of Psychiatry, Washington University School of Medicine.
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine.
Hans OhSuzanne Dworak Peck School of Social Work, University of Southern California.
K Juston OsborneDepartment of Psychiatry, Washington University School of Medicine.
David Aa BarangerDepartment of Pharmacology & Toxicology, Medical College Wisconsin.
Ryan BogdanDepartment of Psychological & Brain Sciences, Washington University in St. Louis.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine.
Funding
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7MABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9MFIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8MABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3MABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7MAdolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7MNIDA NIH HHS K01 DA051759NIDA NIH HHS R01 DA054750NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS R01 MH139880
6 · The paper itselfAbstract
Psychotic-like experiences (PLEs) are common in youth and predict later mental health problems. Bullying victimization is a robust environmental risk factor for psychopathology including PLEs, but whether its association with PLEs reflects shared genetic liability, individual-specific putatively causal effects, or reciprocal processes is unclear. We analyzed seven waves of longitudinal data from the Adolescent Brain Cognitive Development (ABCD) Study, examining associations across the sample in addition to leveraging within-family comparisons among twin and sibling pairs who were concordant or discordant for exposure to bullying victimization. Using linear mixed-effects and cross-lagged models, we found that youth reporting bullying victimization were more likely to endorse significantly distressing PLEs than non-victimized youth (caregiver-reported odds ratio=2.35; youth-reported odds ratio=4.10). Longitudinal analyses revealed bidirectional associations: prior bullying predicted subsequent increases in distressing PLEs, and prior PLEs predicted elevated risk of later bullying victimization. Genetically-informed within-family analyses indicated that both shared genetic influences and individual-specific factors contributed to these associations; critically, bullied youth exhibited higher odds of distressing PLEs than their non-exposed siblings (youth-reported odds ratio=6.67; 95%CI:4.96-8.96), consistent with an individual-specific effect of victimization. Together, these findings suggest that bullying and PLEs are linked through reciprocal developmental processes that are not fully explained by familial confounding. More broadly, our results highlight bullying prevention as a plausible leverage point for reducing early psychosis-spectrum risk and illustrate the value of integrating within-family designs to help disentangle genetic and environmental contributions to mental health outcomes in adolescence.
Indexed as
adolescenceAdolescent Brain Cognitive Development Studybullying victimizationlongitudinalPsychological and Cognitive Sciencespsychotic-like experiencesSocial Sciences
Identifiers
PMID41674625
PMCPMC12889863
What OpenQuestion holds
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LicenceCC BY-NC-ND
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