Evidence map›Paper›PMID 41674617›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Socially Grounded Exemplars Improve Synthetic Conversations for Health-Related Social Needs Navigation.

Syed-Amad Hussain, Daniel I Jackson, Samanvith Thotapalli, Marissa B McClellan, Madeleine Stanco, Grace Varney, Sterling Gleeson, Florencia Nugroho, William Leever, Eric Fosler-Lussier and 1 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Syed-Amad HussainAbigail Wexner Research Institute at Nationwide Children's Hospital.ORCID 0000-0002-7529-8644
Daniel I JacksonAbigail Wexner Research Institute at Nationwide Children's Hospital.
Samanvith ThotapalliThe Ohio State University Department of Neuroscience.
Marissa B McClellanAbigail Wexner Research Institute at Nationwide Children's Hospital.
Madeleine StancoAbigail Wexner Research Institute at Nationwide Children's Hospital.
Grace VarneyAbigail Wexner Research Institute at Nationwide Children's Hospital.
Sterling GleesonAbigail Wexner Research Institute at Nationwide Children's Hospital.
Florencia NugrohoAbigail Wexner Research Institute at Nationwide Children's Hospital.
William LeeverAbigail Wexner Research Institute at Nationwide Children's Hospital.
Eric Fosler-LussierThe Ohio State University Department of Computer Science.ORCID 0000-0001-8004-5169
Emre SezginAbigail Wexner Research Institute at Nationwide Children's Hospital.ORCID 0000-0001-8798-9605

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUM1TR004548 · NCATS · OHIO STATE UNIVERSITY · PI CYNTHIA A GERHARDT, JULIE A. JOHNSON · 2023 to 2026
$22.0M
NCATS NIH HHS UM1 TR004548
6 · The paper itself

Abstract

Health-Related Social Needs (HRSNs) significantly impact health outcomes, yet traditional care often fails to address them effectively. While conversational agents offer scalable support, their deployment is hindered by privacy risks and a lack of specialized training data for clinical applications. Synthetic data generation offers a solution to address this gap; standard pipelines often prompt LLMs using structured user personas, comprising demographics, constraints, and goals, to emulate dialogues. However, current methods relying on coarse demographic attributes often yield generic or stereotyped personas that lack real-world nuance. To improve the realism of synthetic data, we introduce Socially Grounded Exemplars (SGEs), which translate abstract persona attributes into granular, conversational descriptors. We implemented a two-stage pipeline using GPT-4o to generate SGEs, which then grounded synthetic dialogue generation under various prompting strategies. We evaluated the approach using automatic diversity metrics (Vendi Score) and blinded pairwise preference ratings by community behavioral health specialists (CBHS). Validation confirmed the feasibility of input generation, with GPT-4o achieving an 85% term acceptability rate for SGEs. In conversation generation, dynamic SGEs significantly improved lexical diversity, achieving a Vendi Score of 289.41 compared to 252.36 for the control baseline. CBHS ranked the model combining dynamic SGEs with implicit name-based cueing highest (Bradley-Terry Score: 0.753), surpassing both the SGE-only model (0.663) and the explicit demographics model (0.348). Raters favored the name-augmented model for "Specificity & Natural Authenticity" (30.0%), while explicit demographic labeling reduced perceived authenticity. We show SGEs leverage LLM parametric knowledge to produce diverse synthetic data, surpassing the limitations of rigid demographic ontologies. Our findings indicate that implicit cueing through names yields more authentic representations than explicit labeling, reducing the risk of stereotyped outputs. This framework supports the creation of privacy-preserving, conversational datasets informing tasks (e.g. evaluation, agentic workflows, and model distillation) in sensitive healthcare contexts.

Identifiers

PMID41674617
PMCPMC12889791

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LicenceCC BY-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.