Evidence map›Paper›PMID 41674589›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Kauro, a graph-based chatbot for high-fidelity information transmission conversations.

Charles Hadley King, Rebekah Barrick, Miguel Almalvez, Kirsten Blanco, Ivan De Dios, Vincent A Fusaro, Emmanuèle Délot, Chris Donohue, Seth Berger, Changrui Xiao and 3 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Charles Hadley KingUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0003-1409-4549
Rebekah BarrickUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0001-8567-7739
Miguel AlmalvezUniversity of California, Irvine, Institute for Clinical and Translational Science.
Kirsten BlancoUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0002-8796-3744
Ivan De DiosUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0009-0006-8552-4621
Vincent A FusaroUniversity of California, Irvine, Institute for Clinical and Translational Science.
Emmanuèle DélotUniversity of California, Irvine, Institute for Clinical and Translational Science.
Chris DonohueUniversity of California, Irvine, Institute for Clinical and Translational Science.
Seth BergerAmbry Genetics Inc.ORCID 0000-0001-7517-4302
Changrui XiaoUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0001-9536-3389
UCI GREGoR Site
Eric VilainUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0002-5557-3709
Jonathan LoTempioUniversity of California, Irvine, Institute for Clinical and Translational Science.ORCID 0000-0001-6897-5419

Funding

Pediatric Mendelian Genomics Research CenterU01HG011745 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Eric J. Vilain · 2021 to 2026
$13.3M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
NCATS NIH HHS UM1 TR004927NHGRI NIH HHS U01 HG011745
6 · The paper itself

Abstract

Across biomedical research and care, many conversations transmit information with profound practical, ethical, and legal consequences. The process of informed consent, where individuals decide to join a study or accept clinical care, is perhaps the most consequential, yet it is also complex, labor-intensive, and variable across sites. Existing platforms for information transmission in the informed consent context largely reproduce static documents and lack reproducibility or auditability, while generative chatbots offer flexibility at the cost of stochasticity, hallucination, and regulatory risk. We present Kauro, an open-source, graph-based chatbot that encodes scripted conversations as version-controlled JavaScript Object Notation (JSON) structures, enabling deterministic traversal (ie, paths through the graph), complete audit logging, and IRB-verifiable oversight. Its modular separation of client, server, and script ensures portability across institutions. By operationalizing constraint rather than flexibility, Kauro reframes deployment of machine intelligence in biomedical communication with reproducibility and auditability, offering a scalable platform generalizable to any domain where conversations demand safety, precision, and trust.

Identifiers

PMID41674589
PMCPMC12889763

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.