Evidence map›Paper›PMID 41674579›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Exhausted T cell phenotypes in disseminated coccidioidomycosis.

Gregory D Whitehill, Alexis V Stephens, Timothy J Thauland, Miguel A Moreno Lastre, Matthew M Tate, Sinem Beyhan, Royce H Johnson, George R Thompson, Maria I Garcia-Lloret, Manish J Butte

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Gregory D WhitehillDivision of Infectious Diseases, Department of Medicine, UCLA, Los Angeles, CA, USA.
Alexis V StephensDepartment of Human Genetics, UCLA, Los Angeles, CA USA.
Timothy J ThaulandDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Miguel A Moreno LastreDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, UCLA, Los Angeles, CA USA.
Matthew M TateVeterans Affairs San Diego Healthcare System, Research Service, 3350 La Jolla Village Drive, San Diego, CA 92161.
Sinem BeyhanVeterans Affairs San Diego Healthcare System, Research Service, 3350 La Jolla Village Drive, San Diego, CA 92161.
Royce H JohnsonDivision of Infectious Diseases, Department of Medicine, UCLA, Los Angeles, CA, USA.
George R ThompsonDivision of Infectious Diseases, Department of Medicine, University of California, Davis, Sacramento, CA, USA.
Maria I Garcia-LloretDepartment of Human Genetics, UCLA, Los Angeles, CA USA.
Manish J ButteDepartment of Human Genetics, UCLA, Los Angeles, CA USA.ORCID 0000-0002-4490-5595

Funding

Innate immune mechanisms of the host response to CoccidioidesU19AI166059 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Royce Harwood Johnson · 2022 to 2026
$10.0M
T-cell Dysfunction as the basis of Disseminated CoccidioidomycosisR21AI149654 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTTE, MANISH J · 2021 to 2022
$421k
NIAID NIH HHS R21 AI149654NIAID NIH HHS U19 AI166059
6 · The paper itself

Abstract

Coccidioidomycosis presents clinically as a spectrum ranging from self-limiting Uncomplicated Valley Fever (UVF) in most cases to life-threatening Disseminated Coccidioidomycosis (DCM) in rare individuals. A few patterns of immunologic deficits allowing for dissemination have been identified, though the specific defects in most individuals with DCM remain undefined. We hypothesized that chronic antigen exposure in DCM engenders a state of T cell exhaustion. From a cohort of over 300 subjects with confirmed diagnoses of coccidioidomycosis, circulating T cell phenotypes were characterized via flow cytometry and

Identifiers

PMID41674579
PMCPMC12889757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.