Evidence map›Paper›PMID 41674565›Full record

ArticleiMetaOmics2025

A reciprocal interaction between L-lysine and

Chun-Hui Jiang, Xue Fang, Wen Huang, Ya-Hui Wang, Le Kang, Peng-Yuan Wang, Chao Xu, Zhao-Shen Li, Wen-Bin Zou, Zhuan Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMetaOmics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chun-Hui JiangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.ORCID https://orcid.org/0000-0002-1237-585X
Xue FangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.ORCID https://orcid.org/0000-0002-4512-1960
Wen HuangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Ya-Hui WangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Le KangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Peng-Yuan WangDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Chao XuDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Zhao-Shen LiDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
Wen-Bin ZouDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.ORCID https://orcid.org/0000-0002-7881-0156
Zhuan LiaoDepartment of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.ORCID https://orcid.org/0000-0001-8506-8159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is a prevalent stress-associated disorder characterised by gut barrier dysfunction and gut-brain axis disturbances. However, the interplay between host metabolites and gut microbes in IBS pathogenesis remains incompletely understood. Here, through integrated microbiome and metabolome profiling of faecal sample from seafarers before and after long-term voyages, we identify a reciprocal interaction between the essential amino acid l-lysine and the gut bacterium

Indexed as

anxietyHoldemanella biformisintestinal barrier functionirritable bowel syndromel‐lysinetryptophan metabolism pathway

Identifiers

PMID41674565
PMCPMC12805995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.