Evidence map›Paper›PMID 41674559›Full record

ArticleJournal of pediatric intensive care2024

Drug Administration Patterns in Patients on Extracorporeal Membrane Oxygenation.

Danielle J Green, Jesse G Norris, Autumn McKnite, Mark W Hall, Kevin M Watt

Abstract read
In one paragraph

Article in Journal of pediatric intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danielle J GreenDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-6924-3797
Jesse G NorrisDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.
Autumn McKniteDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States.
Mark W HallDivision of Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, United States.
Kevin M WattDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States.

Funding

Multidisciplinary Pulmonary and Critical Care Training ProgramT32HL105321 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ramsey Hachem, Robert Paine · 2010 to 2026
$4.5M
Physiologically-Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life SupportR01HD097775 · NICHD · UNIVERSITY OF UTAH · PI WATT, KEVIN M · 2019 to 2023
$2.7M
Investigation of Drug-Drug and Drug-Circuit Interactions in Children on Continuous Renal Replacement TherapyF31DK130542 · NIDDK · UNIVERSITY OF UTAH · PI MCKNITE, AUTUMN · 2022 to 2023
$74k
NHLBI NIH HHS T32 HL105321NICHD NIH HHS R01 HD097775NIDDK NIH HHS F31 DK130542
6 · The paper itself

Abstract

This study aimed to identify drug administration patterns in patients of all ages supported with extracorporeal membrane oxygenation (ECMO) across multiple institutions and determine which of the most commonly administered drugs lack published dosing guidance. We conducted a retrospective, multicenter database study using the TriNetX data network and the Pediatric Health Information Systems database. All adults and children supported with ECMO were included for analysis. Drug exposure and days of use were described according to age category (Infants [<2 years], Children [≥2 and <18 years], and Adults [≥18 years]). The literature was reviewed for the top 50 most commonly administered drugs in all ages; all pharmacokinetic and ex vivo studies were included. A total of 17,909 patients were analyzed. The patient population comprised 24% adults (

Indexed as

critical illnessdatabaseextracorporeal membrane oxygenationintensive care unitspharmacokineticspharmacology

Identifiers

PMID41674559
PMCPMC12890177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.