Structural and dynamic properties of the YTH domain in complex with N

Mingwei Li, Guanglin Chen, Zhiyong Zhang

Abstract read

In one paragraph

Article in Quantitative biology (Beijing, China), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mingwei LiMOE Key Laboratory for Membraneless Organelles & Cellular Dynamics National Science Center for Physical Sciences at Microscale Division of Life Sciences and Medicine, and Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China Hefei 230026 China.

Guanglin ChenDepartment of Physics University of Science and Technology of China Hefei 230026 China.

Zhiyong ZhangMOE Key Laboratory for Membraneless Organelles & Cellular Dynamics National Science Center for Physical Sciences at Microscale Division of Life Sciences and Medicine, and Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China Hefei 230026 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: N Method: This work presents results of accelerated molecular dynamics (aMD) simulations at the timescale of microseconds. Principal component analysis (PCA), molecular mechanics generalized Born surface area (MM/GBSA) calculations, contact analysis and contact-based principal component analysis (conPCA) provide new insights into structure and dynamics of the YTH-RNA complex. Results: The aMD simulations indicate that the recognition loop has a larger movement away from the binding pocket in the YTH-A3 RNA than that in the YTH-m Conclusion: The results are in good agreement with higher structural stability of the YTH-m

Indexed as

binding free energycontact‐based PCAprincipal component analysis (PCA)RNA methylationYTH‐m6A3 RNA

Identifiers

PMID41674540

DOI10.15302/J-QB-022-0297

PMCPMC12807427

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.