ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Applying a systemic approach that extends beyond the brain to Alzheimer's disease pathogenesis.Communications medicine · 2026Article
- Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In Alzheimer's disease (AD) and vascular dementia (VaD), comorbidities shape disease trajectories and care needs, yet their timing across the lifespan remains poorly understood. Methods: We analyzed comorbidities using in-patient hospital International Classification of Diseases 10th Revision codes in 10,730 UK Biobank participants with AD or VaD, spanning 20 years before to 10 years after diagnosis. Logistic regression and Bayesian network analysis identified time- and subtype-specific risk patterns, validated against controls. Results: Distinct comorbidities emerged decades before diagnosis. In AD, depressive episodes, osteoporosis, and type 1 diabetes appeared up to 20 years pre-diagnosis, while VaD was characterized by early cerebral infarctions, type 1 diabetes, intestinal disorders, and rheumatoid arthritis, absent in controls. Discussion: Although restricted to severe populations captured in in-patient data, excluding primary care, these findings reveal time-dependent prodromal patterns in AD and VaD, highlighting opportunities for targeted screening, prevention, and early intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.