SynthesisWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta-Analysis.
Synthesis in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta-Analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes-related lower extremity amputations (LEAs) are a significant global issue, exacerbated by the rising prevalence of diabetes and peripheral artery disease (PAD). Traditional revascularization techniques often fail in patients with severe vascular damage or comorbidities. Tibial Osteodistraction angiogenesis (ODA) represents a novel approach, leveraging angiogenesis to improve perfusion and wound healing. A systematic review was conducted across four databases. Inclusion criteria focused on studies evaluating ODA in diabetic foot ulcers and chronic ischemic wounds. Outcomes analysed included amputation rates, wound healing, mortality, and safety metrics. Eighteen studies (n = 3000 treated with ODA) were included, with subjects aged 35-87. Diabetes prevalence was 87.8%. ODA demonstrated high limb salvage rates (92%-100%) and wound healing rates (58%-100%). Pooled analysis revealed amputation rates of 2% and mortality rates of 4%. Angiogenic cytokine levels increased post-procedure, suggesting enhanced angiogenesis. Complications were minimal, with a 3% pin-site infection rate and 4% major adverse limb events. ODA offers a promising addition for patients with limb-threatening ischemia, achieving significant improvements in perfusion, wound healing, and limb salvage. Despite study heterogeneity and limitations, ODA's angiogenic benefits warrant further research through randomised clinical trials to validate its efficacy and broaden clinical adoption.
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Registered trials
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