ArticleJournal of basic microbiology2026
Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization.
Article in Journal of basic microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization.Journal of basic microbiology · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid-lowering and multifunctional properties. To enhance MK yield in solid-state fermentation, this study combined atmospheric and room-temperature plasma (ARTP) mutagenesis with L-arginine supplementation. A mutant strain, C-23, was obtained, and the addition of L-arginine increased MK production by 97.3%, reaching 9.45 mg/g. Untargeted metabolomics revealed that L-arginine reshaped metabolic pathways related to amino acids, cofactors, carbohydrates, and lipids, elucidating the mechanism behind MK overproduction. This work provides a strategic approach for developing high-yielding Monascus strains and offers insights into the metabolic regulation of MK biosynthesis.
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