Evidence map›Paper›PMID 41674107›Full record

Trial reportJournal of rehabilitation medicine2026

Predicting effect and evaluating cost-effectiveness of a family intervention after acquired brain or spinal cord injury: a randomized controlled trial.

Karoline Yde Andersen, Frederik Have Dornonville de la Cour, Mia Moth Wolffbrandt, Fin Biering-Sørensen, Juan Carlos Arango-Lasprilla, Pernille Langer Soendergaard, Anne Norup

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of rehabilitation medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karoline Yde AndersenNeurorehabilitation Research and Knowledge Centre, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark. karoline.yde.andersen@regionh.dk.
Frederik Have Dornonville de la CourNeurorehabilitation Research and Knowledge Centre, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark; The Elsass Foundation, Charlottenlund, Denmark.
Mia Moth WolffbrandtNeurorehabilitation Research and Knowledge Centre, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Fin Biering-SørensenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Brain and Spinal Cord Injuries, Rigshospitalet, Glostrup, Denmark.
Juan Carlos Arango-LasprillaDepartment of Cell Biology and Histology, University of the Basque Country UPV/EHU, Leioa, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Pernille Langer SoendergaardNeurorehabilitation-CPH, City of Copenhagen, Hellerup, Denmark.
Anne NorupNeurorehabilitation Research and Knowledge Centre, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo predict treatment response of a family intervention and investigate its cost-effectiveness from a healthcare payer perspective.

designExplorative predictor analyses and trial-based economic evaluation. SUBJECTS/PATIENTS: Participants (n=157) were enrolled 4 months to 2 years after discharge from a specialized neurorehabilitation unit.

methodsInjury type, time since injury, delivery format, and relationship (individual with injury vs family member) were explored as predictors of effect using linear mixed-effect regression. Cost-effectiveness was analysed from a healthcare payer perspective, with incremental cost based on delivery. Incremental health effect was reported for measures on mental health and anxiety and depression symptoms.

resultsThe 4 predictors had negligible to small effects on the treatment response. Incremental cost for the family intervention was estimated at €798.16 (CI: €700.9; €895.5). Incremental health effect was estimated at 5.64 (CI: 2.71, 8.56) points on the Mental Component Summary at 2 months' follow-up. At a willingness-to-pay threshold of €300, the probability of the intervention being cost-effective was 99.8% for the Mental Component Summary.

conclusionThe predictors showed no or little effect on the treatment response, and the cost-effectiveness analysis showed the probabilities of the intervention being cost-effective from a health payer perspective.

Indexed as

Brain InjuriesFamily TherapySpinal Cord InjuriesAdultCost-Benefit AnalysisCost-Effectiveness AnalysisFemaleHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID41674107
PMCPMC12914643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.