Evidence map›Paper›PMID 41674073›Full record

ArticleJournal of cachexia, sarcopenia and muscle2026

Loss of Lean Mass in Rheumatoid Arthritis Is Associated With Loss of Total and Visceral Fat.

Joshua F Baker, Jon T Giles, Babette Zemel, Katherine D Wysham, Jin Long, Mary Leonard, Patricia Katz

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua F BakerCorporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0799-7563
Jon T GilesCedars-Sinai Medical Center, Los Angeles, California, USA.
Babette ZemelUniversity of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA.
Katherine D WyshamVA Puget Sound Health Care System, Seattle, Washington, USA.
Jin LongStanford University, Palo Alto, California, USA.
Mary LeonardStanford University, Palo Alto, California, USA.
Patricia KatzUniversity of California San Francisco, San Francisco, California, USA.

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
CSRD VA I01 CX001703CSRD VA IK2 CX000955Johns Hopkins Bayview Medical Center General Clinical Research Center M01RR02719National Center for Research Resources through a University of California San Francisco Clinical and Translational Sciences Institute UL1-RR024131NCRR NIH HHS UL1 RR024134NIAMS NIH HHS P60-AR053308NIH HHS K12 HD068373 (DRW)NIH NIAMS AR050026-01VA Career Development Award IK2CX002351
6 · The paper itself

Abstract

purposeRheumatoid cachexia has been described as a process of concurrent muscle loss and gain of adipose tissue. We evaluated longitudinal changes in body composition in patients with rheumatoid arthritis (RA) to evaluate the changes in adiposity that accompany loss of lean mass.

methodsWe combined and assessed three independent longitudinal RA cohorts that included assessments of body composition. Whole body DXA was performed in all participants to quantify appendicular lean mass index (ALMI, kg/m

resultsAmong 451 patients with a mean (SD) age of 58.3 (10.5), the mean (SD) ALMI was 6.97 (1.41) kg/m

conclusionsIn RA, loss of lean mass tends to occur in the context of a loss of weight and a loss of both total and visceral adiposity. These observations help to inform our understanding of the mechanisms leading to loss of muscle and rheumatoid cachexia in RA as well as to inform potential screening practices.

Indexed as

Arthritis, RheumatoidIntra-Abdominal FatAbsorptiometry, PhotonAgedBody CompositionBody Mass IndexCachexiaFemaleHumansLongitudinal StudiesMaleMiddle Agedadiposityrheumatoid arthritissarcopenia

Identifiers

PMID41674073
PMCPMC12894774

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.