ReviewCell communication and signaling : CCS2026
RNA G-quadruplexes in oncogene regulation and as emerging targets for cancer therapy.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
RNA G-quadruplexes (rG4s) are RNA secondary structures formed by the folding of guanine-rich sequences. As emerging post-transcriptional regulatory elements, rG4s play crucial roles at multiple levels of gene expression regulation. In recent years, the pivotal roles of rG4s in cancer initiation and progression have gained increasing attention. In tumor biology, the structural stability and dynamic folding properties of rG4s directly influence the expression of key oncogenes, thereby regulating malignant phenotypes such as tumor cell proliferation, invasion, metastasis, and drug resistance. We summarize the diverse mechanisms by which rG4s regulate cancer-related genes and review recent advances in their roles in translational control, alternative splicing, mRNA stability, and noncoding RNA functions. Furthermore, we discuss emerging rG4-targeting technologies and their potential to specifically modulate rG4-mediated gene expression in tumors. Our aim is to provide new insights into the mechanisms of rG4 function in cancer and to offer novel strategies for developing targeted cancer therapies directed at specific rG4-containing transcripts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.