ArticleBMC veterinary research2026
Dictyota dichotoma extract as a potential nutraceutical for male fertility: insights into semen quality, testicular histology, immunomodulation, and anti-inflammatory markers in rabbit bucks.
Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oral Administration of a Probiotic Blend Modulates Immuno-Antioxidant Status, Semen Quality, Cytokines, and Endocrine Profiles in Rabbit Bucks.Probiotics and antimicrobial proteins · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated for the first time the potential symbiotic effects of using Dictyota dichotoma extract (DDE) to enhance reproductive health in bucks. The study examined semen quality, immune function, blood biochemistry, inflammatory markers, antioxidant status, testicular histology, and seminal plasma contents in rabbit bucks. A total of forty bucks (n = 10 in each group) were randomly allocated into four groups and fed a basal diet with 0, 100, 200, and 400 mg of DDE/kg diets for 3 months. The results indicated that DDE (200 mg/kg) treatment linearly enhanced sperm concentration, membrane function, motility, and viability (P < 0.01), while significantly reducing sperm abnormalities in a quadratic trend (P < 0.05). Serum concentrations of total glycerides and lactate dehydrogenase decreased linearly, while creatinine, gamma-glutamyl transferase, and urea levels exhibited a significant quadratic reduction (p < 0.01) in rabbits fed DDE-supplemented diets. Dietary DDE (200 or 400 mg/kg) inclusion linearly increased plasma SOD, GPX (quadratic effect, p < 0.01) and catalase activities, while quadratically decreased MDA levels (p < 0.01). Immunological parameters, including IgG and nitric oxide levels, exhibited a significant linear increase (p < 0.01) with the best dose 200 mg of DDE supplementation. Similarly, IgM levels and lysozyme activity were quadratically improved in groups fed DDE-fortified diets (p < 0.01). DDE supplementation (400 mg /kg) quadratically reduced capaspae-3 and IFN-γ (p < 0.01) and linearly decreased Bcl-2 (p < 0.01). In contrast, cytochrome C levels were quadratically enhanced across the DDE treatment groups (p < 0.01). DDE inclusion linearly improved seminal antioxidant activities SOD, and CAT and quadratically improved GPX (p < 0.01). Additionally, seminal plasma MDA levels were linearly reduced by DDE treatment (p < 0.01). In sperm cells, the activities of mitochondrial enzymes such as MDH (quadratic effect, p < 0.01) and SDH (linear effect, p < 0.001) were significantly improved in all DDE-supplemented groups compared to the control group. Histology, the DDE treatment enhanced the testicular integrity as evidenced by an increase in the numbers and diameters of seminiferous tubules (ST), as well as the heights of the germinal epithelium of ST (p < 0.05). Overall, dietary inclusion of DDE may have beneficial effects on the reproductive health of bucks by regulating sperm function, blood health, improving antioxidant and immune responses, and reducing inflammatory signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.