ArticleBMC cardiovascular disorders2026
Assessment of left atrial function following patent foramen ovale closure using four-dimensional auto left atrial quantification.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the application of four-dimensional auto left atrial quantification (4D Auto LAQ) technology in assessing left atrial (LA) function following transcatheter closure of a patent foramen ovale (PFO).
methodsIn this prospective study, patients diagnosed with a PFO and scheduled for transcatheter closure at the First Affiliated Hospital of Xinxiang Medical University underwent transthoracic echocardiography and 4D Auto LAQ examinations before the procedure and at 1 day and 1, 3, 6 and 12 months after procedure. Left atrial structural parameters, volumetric parameters and strain parameters were measured. Repeated measures analysis of variance was used to analyse parameter changes over time.
resultsThirty-two patients (13 men, 19 women; mean age: 44.0 ± 9.5 years) were included in the final analysis. Left atrial volume minimum increased significantly following closure (P = 0.007), whereas total LA ejection fraction (LAEF) and active LAEF decreased (P < 0.001 and P = 0.019, respectively). Several LA strain indices, including reservoir strain (LASr) and circumferential reservoir/conduit/contraction strains (LASr_c, LAScd_c and LASct_c), showed significant postoperative reductions (all P < 0.010). No significant differences were observed in other tracked measurements over time (all P > 0.050). The observed changes occurred early after closure and appeared to stabilise during subsequent follow-up.
conclusionFour-dimensional auto left atrial quantification could provide a sensitive and non-invasive approach to evaluate LA volume and strain changes following PFO closure. Given the observational, non-comparative design, causal inference cannot be made; the detected alterations should be interpreted as hypothesis generating. Larger controlled studies incorporating clinical endpoints are warranted to determine the mechanisms and clinical relevance of these imaging changes.
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