ArticleParasites & vectors2026
Single-cell transcriptome sequencing reveals immunological mechanisms by which recombinant Echinococcus granulosus P29 protein alleviates airway inflammation in mice with allergic asthma.
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAllergic asthma is a major health burden. The "hygiene hypothesis" links parasitic infections to the prevention and treatment of allergic asthma. Recombinant Echinococcus granulosus P29 protein (rEg.P29) has been shown to induce the conversion of CD4
methodsLung histiocytes from mice were examined using single-cell transcriptome sequencing in combination with experimental methods, such as flow cytometry. Serum levels of total immunoglobulin E (IgE), ovalbumin (OVA)-IgE, and inflammatory factors were measured using enzyme-linked immunosorbent assays and cytometric bead array. Finally, cellular communication analysis of target immune cells was performed using bioinformatics approaches.
resultsrEg.P29 significantly alleviated OVA-induced histopathological changes in the lungs of mice with allergic asthma; downregulated serum IgE levels; reduced lung tissue eosinophils, Th2, and Th17 cells; and increased Th1 and Treg cells in mouse lung tissues. The possibility of an interconversion between proliferative pathogenic Th2 cells and stem cell-like Th2 cells was noted. In Treg cells, Nr4a1 targets were detected, and a Lag3
conclusionsrEg.P29 can effectively alleviate OVA-induced airway inflammation in mice with allergic asthma, and multiple T cell subpopulations in lung tissues are collectively involved in the immunological effects of rEg.P29.
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