ArticleJournal of health, population, and nutrition2026
Traditional Chinese medicine constitution characteristics and influencing factors for acute mountain sickness susceptibility in rapidly ascending high-altitude populations: a cross-sectional survey.
Article in Journal of health, population, and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A randomized controlled trial protocol of herbal formulas for modifying susceptible body constitution to enhance COVID-19 resistance in Hong Kong residents.Journal of thoracic disease · 2026Article
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20 authors.
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Abstract
backgroundAcute mountain sickness (AMS) presents a significant health risk for individuals rapidly ascending to high altitudes, with its occurrence influenced by both environmental and individual factors. The Traditional Chinese Medical Constitution (TCMC), a holistic framework describing an individual's health disposition and disease susceptibility shaped by both innate and acquired factors, may be linked to AMS susceptibility. However, evidence supporting this connection is scarce.
objectiveThis study aims to explore the TCMC types most susceptible to AMS and identify key influencing factors in populations rapidly ascending to Tibet.
methodsA cross-sectional study was conducted with 1,482 eligible healthy male participants aged 18-40 years. Data were collected at two time points-before and after exposure to a high-altitude environment-covering three categories: (1) Baseline physiological measurements, including blood pressure, heart rate, peripheral oxygen saturation (SpO
resultsThe overall AMS incidence was 32.9% (488/1482). The prevalence of unbalanced constitutions was significantly higher in the AMS group compared to the non-AMS group (32.6% vs. 7.6%; P < 0.001). Among AMS patients with unbalanced constitutions, Qi-deficiency was the most prevalent (78.0%). The highest AMS incidence (72.9%) was observed in individuals with a Qi-deficiency constitution. Multivariable analysis identified anxiety (OR = 1.16, 95% CI: 1.08-1.25, P < 0.001), insomnia (OR = 1.09, 95% CI: 1.03-1.16, P = 0.003), unbalanced constitution tendency (OR = 1.06, 95% CI: 1.02-1.10, P = 0.002), and lower SpO
conclusionQi-deficiency is the most common TCMC type associated with AMS susceptibility. Key modifiable risk factors include insomnia, anxiety, and low SpO
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