Evidence map›Paper›PMID 41673702›Full record

ArticleBMC psychology2026

Neuroticism and adolescent depression in China: a chain mediation model of interpersonal sensitivity and loneliness.

Lijia Gu, Zhangyu Cheng, Kezhen Lv, Jianing Xu, Ke Huang, Shengjie Xu, Yuzheng Wang, Yuqi Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lijia GuDepartment of Psychology, School of Education and Psychology, Shaoxing University, 900 Chengnan Avenue, Yuecheng District, Shaoxing, Zhejiang Province, 312000, China.
Zhangyu ChengThe Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, 108 Xueshu Road, Chashan District, Wenzhou, Zhejiang Province, 325035, China.
Kezhen LvThe Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, 108 Xueshu Road, Chashan District, Wenzhou, Zhejiang Province, 325035, China.
Jianing XuThe Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, 108 Xueshu Road, Chashan District, Wenzhou, Zhejiang Province, 325035, China.
Ke HuangBasis International School of Guangzhou, 8 Xingke Road, Science City, Huangpu District, Guangzhou, Guangdong Province, 510000, China.
Shengjie XuThe Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, 108 Xueshu Road, Chashan District, Wenzhou, Zhejiang Province, 325035, China.
Yuzheng WangState Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. wangyz@psych.ac.cn.
Yuqi SunThe Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, 108 Xueshu Road, Chashan District, Wenzhou, Zhejiang Province, 325035, China. yuqisun@wmu.edu.cn.

Funding

Cultivation Project of Leading Talents for Philosophy and Social Science Planning in Zhejiang Province: Research on the Coping Behavior of the Public under the Challenge of Artificial Intelligence 25YJRC008ZD-2Shaoxing Educational Science Planning Project SGJ202207the 2022 Zhejiang Provincial Philosophy and Social Sciences Planning Youth Project 22NDQN274YBWenzhou basic scientific research project [R20240070], and Natural Science Basic Research Program of Shaanxi 2022JZ-13
6 · The paper itself

Abstract

objectiveThis study aimed to explore the chain mediating effects of interpersonal sensitivity and loneliness in the relationship between neuroticism and depression among Chinese treatment-seeking adolescents recruited from outpatient mental health services. The study sought to understand how neuroticism influences depression through these two mediators.

methodA sample of 511 treatment-seeking adolescents was investigated using the Eysenck Personality Questionnaire (EPQ), the Interpersonal Sensitivity Subscale of the Symptom Checklist‑90 (SCL-90), the Illinois Loneliness Questionnaire, and Zung’s Self-Rating Depression Scale (SDS).

resultsThe results showed significant positive correlations among neuroticism, interpersonal sensitivity, loneliness, and depression. Neuroticism predicted depression both directly and indirectly through interpersonal sensitivity and loneliness, which together formed a significant chain‑mediated pathway between neuroticism and depression.

conclusionsThe findings contribute to a deeper understanding of how neuroticism affects depression in treatment-seeking adolescent populations and provide practical guidance for improving clinical assessment and intervention for adolescent depression.

Indexed as

DepressionInterpersonal RelationsLonelinessNeuroticismAdolescentChinaFemaleHumansMaleModels, PsychologicalAdolescentChain mediationDepressionInterpersonal sensitivityLonelinessNeuroticism

Identifiers

PMID41673702
PMCPMC13014820

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.