Evidence map›Paper›PMID 41673656›Full record

ReviewCell communication and signaling : CCS2026

The unseen architects of metastasis: coagulation factors in pre-metastatic niche development.

Haoyu Huang, Xiangtong Lu, Yang Liu, Yuxin Zhang, Jianhao Zhan, Wenjuan Zeng, Chengpeng Sun, Benjie Li, Yujun Zhang, Qixian Wang and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haoyu Huang *Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Rd., Nanchang, Jiangxi, 330006, China.
Xiangtong Lu *Department of Pathology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Rd., Nanchang, Jiangxi, 330006, China.
Yang Liu *Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Rd., Nanchang, Jiangxi, 330006, China.
Yuxin ZhangDepartment of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Rd., Nanchang, Jiangxi, 330006, China.
Jianhao ZhanJiangxi Medical College, Huankui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China.
Wenjuan ZengJiangxi Medical College, Huankui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China.
Chengpeng SunJiangxi Medical College, Huankui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China.
Benjie LiQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Yujun ZhangJiangxi Medical College, Huankui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China.
Qixian WangQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Zijun DingSchool of Ophthalmology and Optometry, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Lingling YangDepartment of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1 Minde Rd., Nanchang, Jiangxi, 330006, China. eleanyang2008@163.com.

Funding

Interdisciplinary innovation fund of Nanchang University 9167-28220007-YB2108Jiangxi Provincial Health Commission Science and Technology Project 202410031Natural Science Foundation of Jiangxi Province 20242BAB25515the National Natural Science Foundation of China 82103655The Second Affiliated Hospital of Nanchang University Funding Program 2024efyC07
6 · The paper itself

Abstract

Cancer metastasis, the leading cause of cancer-related deaths, is a complex process driven by the interplay of multiple factors. Pre-metastatic niche (PMN), formed in distant organs before the arrival of circulating tumor cells (CTCs), provides a favorable environment for CTC colonization and growth. While traditionally known for their role in hemostasis, coagulation factors are increasingly recognized for their significant contributions to tumor development and progression. This review first discusses the multifaceted role of coagulation factors in preparing the PMN for tumor cell colonization. We explore the mechanisms by which coagulation factors, including platelets, fibrinogen, thrombin, and tissue factors (TFs), contribute to PMN formation and metastasis. These factors, through their interactions with tumor cells and the surrounding microenvironment, activate endothelial cells, recruit immune cells, release pro-angiogenic factors, and promote inflammation and extracellular matrix (ECM) remodeling, ultimately facilitating tumor cell colonization and growth. Understanding the interplay between coagulation and metastasis helps provide novel insights and directions for clinical anti-cancer treatment.

Indexed as

Blood Coagulation FactorsNeoplasm MetastasisNeoplasmsAnimalsHumansNeoplastic Cells, CirculatingTumor MicroenvironmentBlood Coagulation FactorsCoagulation factorsFibrinogenPlateletsPre-metastatic nicheThrombinTumor metastasis

Identifiers

PMID41673656
PMCPMC12998383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.