Evidence map›Paper›PMID 41673565›Full record

ArticleJournal of dental research2026

Sfrp4 Is Required for Proper Dental Formation and Stem Cell Regulation.

G Sarra, S Parsaei, M P Gomes, Y-C Lin, A C Pedroni, D Raval, D Hu, S Berry, R Baron, F B Bidlack and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

G SarraDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.ORCID 0000-0002-7238-0749
S ParsaeiDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
M P GomesDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.ORCID 0000-0002-4466-0794
Y-C LinDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
A C PedroniDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
D RavalDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
D HuDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
S BerryDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
R BaronDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
F B BidlackCraniofacial Biology and Bioengineering, ADA Forsyth Institute, Somerville, MA, USA.
F GoriDivision of Bone and Mineral Research, Department of Oral Medicine Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.ORCID 0000-0001-5685-8303

Funding

Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formationR01DE029615 · NIDCR · HARVARD MEDICAL SCHOOL · PI GORI, FRANCESCA · 2020 to 2024
$2.0M
NIDCR NIH HHS R01 DE029615
6 · The paper itself

Abstract

Our studies have established that loss-of-function mutations in the Wnt signaling antagonist

Indexed as

IncisorOdontogenesisProto-Oncogene ProteinsStem CellsAnimalsDental EnamelDental PulpDentinogenesisMesenchymal Stem CellsMiceMolarOdontoblastsPeriodontal LigamentSecreted Frizzled-Related ProteinsTooth ApexTooth RootProto-Oncogene ProteinsSecreted Frizzled-Related ProteinsSfrp4 protein, mouseameloblastsdentinogenesisincisorspyle diseasestem cellsWnt signaling pathways

Identifiers

PMID41673565
PMCPMC13308347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.