Evidence map›Paper›PMID 41673445›Full record

ArticleThe EMBO journal2026

STIM1-containing contact sites promote direct calcium flux from the endoplasmic reticulum to mitochondria.

Yolanda Orantos-Aguilera, Irene Sanchez-Lopez, Carlos Pascual-Caro, Patricia Gómez-Suaga, Estela Area-Gomez, Eulalia Pozo-Guisado, Jorge Montesinos, Francisco Javier Martin-Romero

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yolanda Orantos-Aguilera *Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.
Irene Sanchez-Lopez *Department of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.
Carlos Pascual-CaroDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain.
Patricia Gómez-SuagaDepartment of Biochemistry and Molecular Biology, School of Nursing and Occupational Therapy, Universidad de Extremadura, Cáceres, Spain.
Estela Area-GomezDepartment of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain.ORCID http://orcid.org/0000-0002-0962-1570
Eulalia Pozo-GuisadoInstitute of Molecular Pathology Biomarkers, Universidad de Extremadura, Badajoz, Spain.
Jorge MontesinosDepartment of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain. jorge.montesinos@cib.csic.es.ORCID http://orcid.org/0000-0002-9767-2246
Francisco Javier Martin-RomeroDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Universidad de Extremadura, Badajoz, Spain. fjmartin@unex.es.ORCID http://orcid.org/0000-0001-6796-7396

Funding

EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA) HORIZON-MSCA-2022-PF-01 101106857MEC | Agencia Estatal de Investigación (AEI) PID2020-112997-GBI00MEC | Instituto de Salud Carlos III (ISCIII) CB06/05/0041Ministerio de Ciencia, Innovación y Universidades (MCIU) RYC2022-035146-IMinisterio de Universidades (MU) FPU2019/00694Talento Cesar Nombela Comunidad de Madrid T1SAL-GL-31373
6 · The paper itself

Abstract

STIM1 is a transmembrane protein localized in the endoplasmic reticulum (ER), where it acts as a calcium ion sensor, activating store-operated Ca

Indexed as

CalciumEndoplasmic ReticulumMitochondriaNeoplasm ProteinsStromal Interaction Molecule 1AnimalsHEK293 CellsHSP70 Heat-Shock ProteinsHumansMembrane ProteinsMitochondria Associated MembranesMitochondrial ProteinsProtein BindingCalciumglucose-regulated proteinsHSP70 Heat-Shock ProteinsMembrane ProteinsMitochondrial ProteinsNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1CalciumGRP75MAMMitochondriaSTIM1

Identifiers

PMID41673445
PMCPMC12953705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.