Evidence map›Paper›PMID 41673395›Full record

ArticleNature communications2026

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design.

Linling He, Yi-Zong Lee, Yi-Nan Zhang, Maddy L Newby, Benjamin M Janus, Fabrizio G Gonzalez, Garrett Ward, Connor DesRoberts, Shr-Hau Hung, Erick Giang and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Linling HeDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Yi-Zong LeeDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5651-863X
Yi-Nan ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9053-5890
Maddy L NewbySchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, UK.
Benjamin M JanusDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-6290-8300
Fabrizio G GonzalezDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0009-0000-1864-8233
Garrett WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Connor DesRobertsDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Shr-Hau HungDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9067-2035
Erick GiangDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Joel D AllenSchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0003-2547-968X
Liudmila KulakovaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.
Eric A TothDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-0766-5131
Thomas R FuerstDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-9766-9995
Mansun LawDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8934-9756
Gilad OfekDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-0677-4467
Max CrispinSchool of Biological Sciences, Highfield Campus, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0002-1072-2694
Jiang ZhuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. jiang@scripps.edu.ORCID http://orcid.org/0000-0003-0259-7157

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Novel HCV vaccine antigens and nanoparticlesP01AI168251 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Mansun Law · 2022 to 2026
$12.6M
Rational design and efficacy testing of vaccines against HCVR01AI168048 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Alexander Andrianov, Thomas R Fuerst · 2022 to 2026
$7.1M
Understanding human antibody responses to chronic viral hepatitis CR01AI168917 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Mansun Law · 2022 to 2026
$3.1M
NIAID NIH HHS P01 AI168251NIAID NIH HHS R01 AI168048NIAID NIH HHS R01 AI168917NIH HHS 75N91019D00024U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI168251
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. Development of an E1E2-based HCV vaccine has been hindered by the difficulty of producing a soluble E1E2 (sE1E2) antigen that faithfully recapitulates the native virion-associated heterodimer. Guided by cryo-electron microscopy (cryo-EM) structures, we engineer genotype 1a H77 sE1E2 by truncating the E1 and E2 stems (Cut

Indexed as

HepacivirusHepatitis CNanoparticlesViral Envelope ProteinsViral Hepatitis VaccinesAnimalsAntibodies, NeutralizingCryoelectron MicroscopyEpitopesFemaleHepatitis C AntibodiesHumansMiceNanovaccinesProtein MultimerizationProtein Subunit VaccinesAntibodies, NeutralizingE1 protein, Hepatitis C virusEpitopesglycoprotein E2, Hepatitis C virusHepatitis C AntibodiesNanovaccinesProtein Subunit VaccinesViral Envelope ProteinsViral Hepatitis Vaccines

Identifiers

PMID41673395
PMCPMC13005016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.