Evidence map›Paper›PMID 41673393›Full record

ArticleScientific reports2026

UV-induced immune modulation in the lung niche slows cancer progression.

Avishai Maliah, Shivang Parikh, Andrew C Stevenson, Dan Bijaoui, Esther Goodman, Yuval Sade, Roma Parikh, Gal Binshtok, Paulee Manich, Tamar Golan and 11 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Avishai MaliahDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel. avishaimaliah@gmail.com.
Shivang ParikhDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Andrew C StevensonSchool of Geosciences, University of Edinburgh, Edinburgh, UK.
Dan BijaouiDepartment of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem, Israel.
Esther GoodmanDepartment of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem, Israel.
Yuval SadeDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Roma ParikhDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Gal BinshtokDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Paulee ManichDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Tamar GolanDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Itay TalDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Justine Del RioGustave Roussy Cancer Campus, INSERM U1015, Universite Paris-Saclay, 114 Rue Edouard Vaillant, 94800, Villejuif, France.
Richard WellerCentre for Inflammation Research and Edinburgh Skin Network, University of Edinburgh, Edinburgh, EH8 9XP, UK.
Amaya VirósSkin Cancer and Ageing Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Ruth PercikInstitute of Endocrinology, Chaim Sheba Medical Center, 5262000, Tel-Hashomer, Israel.
Zvi GranotDepartment of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem, Israel.
Chen LuxenburgDepartment of Cell and Developmental Biology, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Yaron CarmiDepartment of Pathology, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel.
Mehdi KhaledGustave Roussy Cancer Campus, INSERM U1015, Universite Paris-Saclay, 114 Rue Edouard Vaillant, 94800, Villejuif, France.
Chris DibbenSchool of Geosciences, University of Edinburgh, Edinburgh, UK.
Carmit LevyDepartment of Human Genetics and Computational Medicine, Gray Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel. carmitlevy@tauex.tau.ac.il.

Funding

HORIZON EUROPE European Research Council 726225Israel Science Foundation 2017/20
6 · The paper itself

Abstract

Ultraviolet radiation has a well-documented local immunosuppressive effect on the skin that can enhance subcutaneous tumor growth; however, its systemic impact on cancer progression in internal organs remains poorly understood. Here, we show that chronic UVB exposure after melanoma metastasis to the lung inhibits metastatic growth and modestly improves survival in mice. In UK Biobank participants, higher solar radiation exposure is positively associated with improved lung cancer survival. Mechanistically, UVB modulates the tumor immune environment: Mass cytometry of CD45

Indexed as

Lung NeoplasmsMelanomaUltraviolet RaysAnimalsDisease ProgressionFemaleHumansMiceNeutrophilsTumor Microenvironment

Identifiers

PMID41673393
PMCPMC12966383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.