ReviewBrain imaging and behavior2026
Resting-state motor network connectivity as a biomarker of Levodopa response in Parkinson's disease.
Review in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
11 authors.
Funding
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Abstract
backgroundParkinson's disease (PD), the second most common neurodegenerative disorder, affects over 10 million people and leads to progressive motor and non-motor decline. Levodopa (L-DOPA) remains the primary treatment, yet long-term use causes motor fluctuations and dyskinesias, and tools to optimize therapy remain limited.
objectivesThis review systematically evaluates studies assessing how L-DOPA affects functional connectivity within the motor network, to inform more precise and personalized treatment strategies.
methodsA systematic search of PubMed and Web of Science was performed using terms related to PD, L-DOPA, and resting-state connectivity. Included studies examined L-DOPA-induced changes in resting-state functional connectivity within motor network-related regions in humans.
resultsL-DOPA broadly modulates connectivity within motor and cognitive resting-state networks. In 28/32 comparisons, L-DOPA increased striatal connectivity with cortical motor regions, basal ganglia nuclei, the cerebellum, and the brainstem. In 21/26 comparisons, connectivity increased between motor cortical areas, the basal ganglia, thalamus, and cerebellum. In 9/16 comparisons, intracerebral connectivity decreased. In all 9 comparisons, L-DOPA increased cerebellar connectivity with the globus pallidus, midbrain, and brainstem. In all 6 comparisons, connectivity increased within the midbrain and between the midbrain, thalamus, and brainstem.
conclusionThis review consolidates ON/OFF L-DOPA findings to characterize how L-DOPA modulates motor network connectivity. These insights may advance precision therapies, guide individualized dose titration, and support the development of treatments with improved side-effect profiles.
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Registered trials
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