Evidence map›Paper›PMID 41673329›Full record

ArticleCell biology and toxicology2026

Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies.

Peiqi Wang, Haoxin Fu, Jun Wu, Ruibin Li, Lu Cao, Ren-Ai Xu, Weihong Lin

Abstract read
In one paragraph

Article in Cell biology and toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peiqi WangThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Haoxin FuThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Jun WuThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Ruibin LiThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Lu CaoThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Ren-Ai XuThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. xra@wmu.edu.cn.
Weihong LinThe First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. linweihong@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen 21 cardiovascular drugs with a focus on elucidating the metabolic inhibition of acalabrutinib by finerenone in vitro and in vivo. The ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to quantify acalabrutinib and its major active metabolite ACP-5862 in liver microsomes in vitro and in rats in vivo. The half-maximal inhibitory concentrations (IC

Indexed as

BenzamidesPyrazinesAnimalsCytochrome P-450 CYP3ADrug InteractionsHumansMaleMicrosomes, LiverMolecular Docking SimulationRatsRats, Sprague-DawleyTandem Mass SpectrometryacalabrutinibBenzamidesCYP3A4 protein, humanCytochrome P-450 CYP3APyrazinesAcalabrutinibDrug-drug interactionFinerenoneMetabolism

Identifiers

PMID41673329
PMCPMC12982217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.