Observational studyAesthetic plastic surgery2026
ChatGPT-5 Matches Surgeon-Level Assessment of Facelift Candidacy: A Pilot Proof-of-Concept Study.
Observational study in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Article
- Evaluation of Aesthetic Outcomes Following Botulinum Toxin Treatment Using Multimodal Large Language Models: A Paired Before-and-After Analysis.Aesthetic surgery journal. Open forum · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of multimodal artificial intelligence (AI) in plastic surgery is steadily increasing. Whether a general-purpose multimodal AI tool can, from photographs alone, assess facial aging and facelift candidacy at a level comparable to board-certified specialist plastic surgeons remains unknown.
objectivesTo determine if ChatGPT-5 (OpenAI, San Francisco, CA, USA) can identify facial aging features, stratify severity, and judge facelift candidacy from photographs alone, compared with board-certified plastic surgeons.
methodsTwo-center observational pilot. Twenty-two volunteers (mean age 42.0 ± 16.8 years; median 34 years; range 24-80) provided standardized four-view facial composite photographs. Five board-certified plastic surgeons independently completed an eight-item questionnaire per case. ChatGPT-5 assessed the same images with identical wording. Assessments were image-only and blinded (no demographics/history). Surgeon consensus was defined by plurality. Primary outcomes were agreement and Cohen's κ; for ordinal items, weighted κ, Spearman's ρ, and mean absolute error (MAE) were reported. McNemar's test assessed discordance for binary items.
resultsFor facelift candidacy, agreement was 95.5% (21/22; Cohen's κ = 0.91; McNemar P = 1.00). For binary aging features, agreement ranged from 81.8 to 90.9% (κ ≈ 0.61 to 0.81). For ordinal severity (lower face and midface), exact agreement was 77.3%, disagreements were adjacent only, weighted κ = 0.74 to 0.86, Spearman's ρ = 0.84 (P < .001). Inter-surgeon agreement on ordinal items was moderate to fair. For the adjunct-procedure recommendation, Top-1 accuracy was 70.6% (12/17; κ = 0.58) and Top-2 agreement was 77.3% (17/22).
conclusionsIn a blinded, standardized-photograph setting, ChatGPT-5 matched surgeons on binary facelift candidacy assessment and closely tracked severity grading with small, one-level differences at most. These findings may support use as a decision-support tool (triage, patient education) while surgeons retain hands-on examination and personalized planning. Larger, multicenter studies with more diverse image datasets are warranted to confirm generalizability and define deployment standards. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.