ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Multitarget evaluation of 4-substituted 7-hydroxycoumarin derivatives: anticancer activity, topoisomerase I inhibition, and interaction with human serum albumin.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Coumarins are known to provide promising scaffolds for the development of new anticancer drugs, yet their multitarget biological profiles remain insufficiently explored. This study presents a comprehensive evaluation of four newly synthesized 4-substituted 7-hydroxycoumarin derivatives C1-C4, highlighting their combined antiproliferative, enzyme-inhibitory, and pharmacokinetic properties. The compounds were tested for their cytotoxic effects on A549 lung carcinoma cells and CCD-18Co fibroblasts, inhibition of topoisomerase I (Topo I), and binding interactions with human serum albumin (HSA). Derivatives C1, C2, and C4 showed selective suppression of A549 metabolic activity and proliferation, while exhibiting minimal toxicity toward non-cancerous fibroblasts. All compounds inhibited Topo I to varying degrees, with C1 displaying the highest potency, indicating that specific hydroxyl group arrangements are crucial for enzyme inhibition. Fluorescence spectroscopy and molecular docking revealed moderate to high HSA affinity (10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.