ArticleBrain imaging and behavior2026
Multimodal MRI reveals hypothalamic structural-functional alterations associated with bone mineral density loss in postmenopausal women.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Emerging evidence implicates central nervous system dysregulation in the pathogenesis of osteoporosis. However, the role of hypothalamic subregions - a key central hub for homeostasis - in human bone health remains poorly understood. This study aimed to elucidate the structural and functional alterations of hypothalamic subregions in relation to bone mineral density (BMD) loss in postmenopausal women using multimodal MRI. Fifty-four postmenopausal women (18 with osteoporosis, 18 with osteopenia, and 18 healthy controls) underwent 3T MRI. A comprehensive analytical framework was employed, comprising: (1) deep learning-based segmentation of hypothalamic subregions; (2) seed-based functional connectivity analysis using these subregions as regions-of-interest; and (3) shape analysis of connected white matter bundles. Non-parametric statistics and partial correlations were applied to quantify associations between hypothalamic measures and BMD, controlling for covariates. Our analysis revealed multimodal alterations in hypothalamic subregions. Specifically, we observed region-specific volume changes in the right anterior inferior (decrease in osteoporosis) and left posterior hypothalamus (increase in osteoporosis), as well as enhanced functional connectivity between the left anterior inferior hypothalamus and the left superior lateral occipital cortex (sLOC)/precuneus (cluster-level FWE-corrected p = 0.030). Microstructural and shape alterations were also detected in white matter bundles connected to several subregions, though these findings should be interpreted as exploratory due to multiple comparisons. Furthermore, a significant positive correlation was found between the volume of the right anterior superior hypothalamus and BMD in the osteopenia group (r = 0.640, p = 0.004). This study provides preliminary in vivo evidence of multimodal hypothalamic alterations in postmenopausal osteoporosis. Our findings suggest that structural alterations in specific hypothalamic subregions and their functional connectivity with visual-attentional networks may be associated with BMD loss. The volume of the right anterior inferior hypothalamus warrants further investigation as a potential neuroimaging biomarker for fracture risk stratification.
Indexed as
Identifiers
41673184What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.