Evidence map›Paper›PMID 41673158›Full record

ArticleNature2026

CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.

Huigang Shi, Xiaorong Wang, Clinton Yu, Haibin Mao, Fenglong Jiao, Merav Braitbard, Ben Shor, Zhongsheng Zhang, Thomas R Hinds, Shiyun Cao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Huigang ShiDepartment of Pharmacology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2428-2500
Xiaorong WangDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.
Clinton YuDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-2931-5474
Haibin MaoDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Fenglong JiaoDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA.
Merav BraitbardThe Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ben ShorThe Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.
Zhongsheng ZhangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Thomas R HindsDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Shiyun CaoDepartment of Pharmacology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1201-4963
Erkang FanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Dina Schneidman-DuhovnyThe Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0003-0480-0438
Lan HuangDepartment of Physiology and Biophysics, University of California, Irvine, CA, USA. lanhuang@uci.edu.ORCID http://orcid.org/0000-0002-3140-4687
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA, USA. nzheng@uw.edu.ORCID http://orcid.org/0000-0002-1039-1581

Funding

Supplement: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome SystemR35GM145249 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lan Huang · 2022 to 2026
$3.2M
Structural surfaceomics to probe conformation-selective immunotherapy targetsR01CA290875 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lan Huang, Arun P. Wiita · 2024 to 2026
$2.7M
NCI NIH HHS R01 CA290875NIGMS NIH HHS R35 GM145249
6 · The paper itself

Abstract

Orthosteric inhibitors block enzyme active sites and prevent substrates from binding

Indexed as

COP9 Signalosome ComplexMultiprotein ComplexesPeptide HydrolasesCatalytic DomainCryoelectron MicroscopyCullin ProteinsHumansIntracellular Signaling Peptides and ProteinsModels, MolecularNEDD8 ProteinProtein BindingSubstrate SpecificityUbiquitinsCOP9 Signalosome ComplexCOPS5 protein, humanCullin ProteinsIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesNEDD8 ProteinNEDD8 protein, humanPeptide HydrolasesUbiquitins

Identifiers

PMID41673158
PMCPMC13128448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.