Evidence map›Paper›PMID 41673155›Full record

ArticleNature2026

Conformational diversity and fully opening mechanism of native NMDA receptor.

Ruisheng Xu, Qiqi Jiang, Hongwei Xu, Lu Zhang, Xiangzi Hu, Zizhuo Lu, Huaqin Deng, Haolin Xiong, Sensen Zhang, Zhongwen Chen and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ruisheng XuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Qiqi JiangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hongwei XuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Lu ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Xiangzi HuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Zizhuo LuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Huaqin DengInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Haolin XiongInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Sensen ZhangBeijing Life Science Academy, Beijing, China.ORCID http://orcid.org/0000-0001-8827-3959
Zhongwen ChenInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-5218-0152
Yifan GeInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-9135-9569
Zhengjiang ZhuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-3272-3567
Yaoyang ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-5363-9834
Yelin ChenInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-9793-2941
Jingpeng GeSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China. gejp@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0001-6164-1221
Jie YuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. yujie@sioc.ac.cn.ORCID http://orcid.org/0000-0001-9227-038X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that mediate excitatory neurotransmission throughout the brain

Indexed as

Ion Channel GatingReceptors, N-Methyl-D-AspartateAnimalsBrainCryoelectron MicroscopyFemaleGlutamic AcidMiceMice, Inbred C57BLMicroscopy, FluorescenceModels, MolecularProtein ConformationProtein SubunitsSingle Molecule ImagingGlutamic AcidNR2B NMDA receptorProtein SubunitsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41673155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.