Evidence map›Paper›PMID 41673148›Full record

ArticleNature2026

Striatum-wide dopamine encodes trajectory errors separated from value.

Eleanor H Brown, Yihan Zi, Mai-Anh Vu, Safa Bouabid, Jack Lindsey, Chinyere Godfrey-Nwachukwu, Aaquib Attarwala, Ashok Litwin-Kumar, Brian DePasquale, Mark W Howe

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleanor H BrownDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.ORCID 0000-0001-9564-9213
Yihan ZiDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.ORCID 0000-0003-1712-2541
Mai-Anh VuDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Safa BouabidDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.ORCID 0000-0003-4184-3795
Jack LindseyZuckerman Institute, Columbia University, New York, NY, USA.
Chinyere Godfrey-NwachukwuDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Aaquib AttarwalaDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.
Ashok Litwin-KumarZuckerman Institute, Columbia University, New York, NY, USA.
Brian DePasqualeCenters for Systems Neuroscience and Neurophotonics, Boston University, Boston, MA, USA.
Mark W HoweDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA. mwhowe@bu.edu.ORCID 0000-0002-6865-5084

Funding

Striatum Wide Dynamics and Neuromodulation of Cell-Type Specific Striatum Populations during LearningR01MH125835 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HOWE, MARK W · 2021 to 2025
$3.0M
Subcellular Mapping and Post-Synaptic Impacts of Striatal Dopamine Release During BehaviorF32MH120894 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI VU, MAI-ANH · 2019 to 2022
$244k
Establishing a Spatial Map of Dopamine Reward Prediction Error Computations and their Function in Distinct Associative Learning Processes Across the Striatum: a Methodological FrameworkF31NS127536 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BROWN, ELEANOR · 2022 to 2024
$111k
NIMH NIH HHS F32 MH120894NIMH NIH HHS R01 MH125835NINDS NIH HHS F31 NS127536
6 · The paper itself

Abstract

Goal-directed navigation requires animals to continuously evaluate their current direction and speed of travel relative to landmarks to discern whether they are approaching or deviating from their goal. Striatal dopamine release signals the reward-predictive value of cues

Indexed as

Corpus StriatumDopamineMotivationAlgorithmsAnimalsCuesFemaleGoalsLearningLocomotionMaleMiceMice, Inbred C57BLReinforcement, PsychologyRewardDopamine

Identifiers

PMID41673148
PMCPMC13460786

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.