Evidence map›Paper›PMID 41673138›Full record

ArticleNature biomedical engineering2026

Ablation of prostaglandin E

Janina Dörr, Lisa Gregor, Sebastian B Lacher, Arman Oner, Yi Sun, Ignazio Piseddu, Luisa Fertig, Sebastijan Spajic, Stefanie Lesch, Stefanos Michaelides and 21 more

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Janina Dörr *Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9447-882X
Lisa Gregor *Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-3300-7167
Sebastian B Lacher *Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Arman OnerInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Yi SunMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ignazio PisedduInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Luisa FertigInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Sebastijan SpajicInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Stefanie LeschInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Stefanos MichaelidesInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Matthias SeifertInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6581-6196
Adrian GottschlichInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2898-4182
Natasha SamsonInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Lina MajedInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Daria BriukhovetskaInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2073-2335
Donjetë SimnicaInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Viktoria HartmannInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Kathrin GabrielInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0009-0009-6756-0014
Sonia CohenDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Genevieve M BolandBroad Institute of MIT and Harvard, Cambridge, MA, USA.
David Andreu-SanzInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Emanuele CarliniInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Sophia StockInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5072-5013
Anne HoltermannInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Philipp Jie MüllerInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Thaddäus StrzalkowskiInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Marcel P TrefnyInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-6755-7899
Stefan EndresInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Russell W JenkinsMass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6110-2148
Jan P BöttcherInstitute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Sebastian KoboldInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-5612-4673

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101124203
6 · The paper itself

Abstract

The efficacy of chimeric antigen receptor (CAR) T cell therapy in solid cancers is limited by immunosuppression in the tumour microenvironment (TME). Prostaglandin E

Indexed as

DinoprostoneImmunotherapy, AdoptiveNeoplasmsReceptors, Chimeric AntigenReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeT-LymphocytesAnimalsCell Line, TumorGene Knockout TechniquesHumansMiceSignal TransductionTumor MicroenvironmentXenograft Model Antitumor AssaysDinoprostoneReceptors, Chimeric AntigenReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 Subtype

Identifiers

PMID41673138
PMCPMC13099425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.