ArticleCommunications medicine2026
Preoperative lymphocyte signature predicts pancreatic fistula after pancreatoduodenectomy.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03978702 (Pancreatic Surgery), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Pancreatic Surgery: Evaluation of the Impact of Pancreatectomy on Systemic Immunity
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14 authors.
Funding
Abstract
backgroundPostoperative pancreatic fistula (POPF) is the major driver of postoperative morbidity after pancreatoduodenectomy (PD) and a healthcare issue. In patients with pancreatic tumors the occurrence of POPF could lead to a complete failure of the oncologic strategy by delaying or annihilating the delivery of the indicated adjuvant chemotherapy. However, current preoperative prediction models lack precision. This study aimed to determine the ability of a high dimensional analysis of the patient's peripheral immune system before PD to predict POPF.
methodsTwenty-two patients in the prospective IMMUNOPANC trial (NCT03978702) underwent PD. Blood samples collected preoperatively were analyzed by combining single-cell mass cytometry and a sparse machine-learning pipeline, Stabl, to identify the most relevant POPF-predictive features. The logistic regression model output was evaluated using a five-fold cross-validation procedure.
resultsEight (36%) patients experience POPF (grade B, n = 7; grade C, n = 1). The multivariable predictive model includes 11 features-six natural killer, three CD8
conclusionsIn summary, preoperative circulating immune-cell composition can predict POPF in patients undergoing PD. The clinical application of the PFLS may enable the early identification of patients at high risk before pancreatic surgery, giving clinicians the opportunity to anticipate and mitigate POPF risk through tailored strategies in pre-, intra-, and post-operative settings.
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Registered trials
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