Characterization, in-vitro biological and antimicrobial testing of replacing Sr/Ca in wollastonite (Ca

H K Abd El-Hamid, Gehan T El-Bassyouni, Amira M M Amin, Abeer A Abd El-Aty, Emad M M Ewais, Esmat M A Hamzawy

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

H K Abd El-HamidRefractories, Ceramics and Building Materials Department, National Research Centre (NRC), El-Buhouth St., Dokki, Cairo, 12622, Egypt. hanaa772004@yahoo.com.

Gehan T El-BassyouniRefractories, Ceramics and Building Materials Department, National Research Centre (NRC), El-Buhouth St., Dokki, Cairo, 12622, Egypt.

Amira M M AminCeramics Materials Department, Refractories, Central Metallurgical Research and Development Institute (CMRDI), Helwan, Cairo, PC87, Egypt.

Abeer A Abd El-AtyChemistry of Natural and Microbial Products Department, National Research Centre (NRC), El-Buhouth St., Dokki, Cairo, 12622, Egypt.

Emad M M EwaisCeramics Materials Department, Refractories, Central Metallurgical Research and Development Institute (CMRDI), Helwan, Cairo, PC87, Egypt.

Esmat M A HamzawyGlass Research Department, National Research Centre (NRC), El-Buhouth St., Dokki, Cairo, 12622, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strontium-doped wollastonite glass-ceramics with varying Sr concentrations (0.125, 0.25, and 0.50 wt%) were successfully synthesized via a melt-quenching technique and comprehensively evaluated for structural, physical, and biological performance, including in vitro biocompatibility, antimicrobial activity, and cytotoxicity. Characterization using DTA, XRD, and FE-SEM/EDX confirmed progressive hydroxyapatite (HA) formation following 28 days of immersion in simulated body fluid (SBF), with XRD revealing a reduction in wollastonite peaks and distinct HA signals, particularly in Sr-containing samples. FTIR spectra showed intensified phosphate absorption bands, while FE-SEM/EDX analyses highlighted a morphological shift from plate-like structures to needle-like HA crystals. Strontium doping was found to play a key role in guiding HA crystallization pathways while supporting wollastonite's intrinsic isovalent cation exchange capacity. Among all compositions, the W3Sr sample (0.5 wt% Sr) exhibited the best balance of mechanical properties and biological efficacy. Biologically, the material demonstrated dose-dependent antifungal activity against Aspergillus niger (11-18 mm IZD) and Fusarium solani (10-16 mm IZD), no antibacterial activity, and excellent cytocompatibility with BJ1 human fibroblasts. Overall, this Sr-doped wollastonite system shows strong potential for next-generation orthopedic and dental applications, combining Sr-mediated bioactivity, mechanical strength, antifungal efficacy, and cell compatibility.

Indexed as

Anti-Infective AgentsCalcium CompoundsCeramicsSilicatesStrontiumAspergillus nigerBiocompatible MaterialsHumansMaterials TestingMicrobial Sensitivity TestsX-Ray DiffractionAnti-Infective AgentsBiocompatible MaterialsCalcium Compoundscalcium silicateGlass ceramicsSilicatesStrontiumAntibacterialAntifungalCytotoxicityGlass-ceramicsStrontiumWollastonite

Identifiers

PMID41673055

DOI10.1038/s41598-026-36649-1

PMCPMC12905248

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