Evidence map›Paper›PMID 41673053›Full record

ArticleNPJ Parkinson's disease2026

Free water in the external globus pallidus predicts mild cognitive impairment in Parkinson's disease and is associated with serum neurofilament light chain levels.

Huimin Chen, Huijing Liu, Wenyi Kou, Xinxin Ma, Yunfei Long, Dongdong Wu, Wei Du, Jing He, Shuhua Li, Haibo Chen and 1 more

Abstract read
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In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huimin ChenDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Huijing LiuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Wenyi KouDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Xinxin MaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Yunfei LongDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Dongdong WuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Wei DuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Jing HeDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Shuhua LiDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Haibo ChenDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Wen SuDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. suwenbjyy@163.com.

Funding

National High-Level Hospital Clinical Research Funding BJ-2023-067National High-Level Hospital Clinical Research Funding BJ-2024-183
6 · The paper itself

Abstract

This study explored free-water diffusion tensor imaging (FW-DTI) in the basal ganglia as a biomarker for mild cognitive impairment (MCI) in Parkinson's disease (PD). One hundred and fourteen drug-naïve PD patients (without MCI at baseline) and 102 healthy controls (HC) from Parkinson's Progression Markers Initiative (PPMI) were included, and FW-DTI metrics were extracted from the bilateral putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). The result showed that PD-MCI convertors had significantly higher FW in GPe and GPi. Cox regression identified that GPe FW, MDS-UPDRS Part I score, and CSF Aβ

Identifiers

PMID41673053
PMCPMC13005014

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