Evidence map›Paper›PMID 41672969›Full record

ArticleTranslational psychiatry2026

Diverse and location-specific roles of PlexinA2, PlexinA4, and NCAM in developing hippocampal mossy fibers.

Xiao-Feng Zhao, Rafi Kohen, Eljo Y Van Battum, Xiaoman Niu, Ying Zeng, Xiaolu Zhang, Craig N Johnson, Karen Wang, Marieke G Verhagen, Brian C Lim and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiao-Feng ZhaoDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-7574-7163
Rafi KohenDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Eljo Y Van BattumDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Xiaoman NiuDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Ying ZengDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Xiaolu ZhangDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Craig N JohnsonDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Karen WangDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
Marieke G VerhagenDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.
Brian C LimDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Juan A Oses-PrietoDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Joshua M RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
Dawen CaiDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA.
R Jeroen PasterkampDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-1631-6440
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8184-2477
Roman J GigerDepartment of Cell and Developmental Biology, University of Michigan Medical School Ann Arbor, Ann Arbor, MI, USA. rgiger@umich.edu.ORCID http://orcid.org/0000-0002-2926-3336

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mossy fibers (MFs) originate from dentate granule cells and innervate area CA3 of the hippocampus. Upon entry of CA3, MFs partition into two prominent axon bundles, the suprapyramidal tract (SPT) and infrapyramidal tract (IPT) and form lamina specific synaptic contacts in the stratum lucidum (SL) and stratum oriens (SO), respectively. Here we mapped cell type specific gene expression and subcellular distribution of Sema6A and its receptors PlexinA2 (PlxnA2) and PlxnA4. Using a mouse genetic approach, including newly generated mouse lines, we dissected the function of these genes in developing MFs. In Sema6a

Indexed as

Mossy Fibers, HippocampalNerve Tissue ProteinsNeural Cell Adhesion MoleculesReceptors, Cell SurfaceSemaphorinsAnimalsAxonsMiceMice, KnockoutNerve Tissue ProteinsNeural Cell Adhesion MoleculesPlxna2 protein, mousePlxna4 protein, mouseReceptors, Cell SurfaceSema6a protein, mouseSemaphorins

Identifiers

PMID41672969
PMCPMC12963419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.