Evidence map›Paper›PMID 41672926›Full record

ReviewClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2026

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.

Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M F Wiegman, Aurelie Poli, Joanna Jacków-Malinowska, Jack Cheeseman, Daniel I R Spencer and 4 more

Abstract readReview
In one paragraph

Review in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jakub ZydronSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Anishaa BalajiSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Jitesh ChauhanSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.ORCID https://orcid.org/0000-0002-3968-9234
Jack AlderSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Xinyi ChenSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Anna M F WiegmanSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Aurelie PoliNeuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Joanna Jacków-MalinowskaSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Jack CheesemanLudger Ltd., Culham Campus, Abingdon, Oxfordshire, UK.
Daniel I R SpencerLudger Ltd., Culham Campus, Abingdon, Oxfordshire, UK.
James McDonnellRandall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, UK.ORCID https://orcid.org/0000-0001-9037-2980
James SpicerSchool of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London, UK.
Alexandra J McCrawSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.
Sophia N KaragiannisSt. John's Institute of Dermatology, School of Basic and Medical Biosciences & KHP Centre for Translational Medicine, King's College London, Guy's Hospital, London, UK.

Funding

Breast Cancer Now 147KL-Q3CRUK City of London Centre C7893/A29290King's Health Partners Centre for Translational MedicineLuxembourg National Research Fund (FNR) and Fondation Cancer Luxembourg GRALL C24/BM/18858278Medical Research Council MR/R015643/1Télévie-FNRS RESTAGE 7.4576.23Worldwide Cancer Research 24-0087
6 · The paper itself

Abstract

The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective effects against cancer, and evasion pathways that facilitate tumour progression. AllergoOncology sheds light on cancers with poor prognosis, including glioma, where evidence has pointed to allergic triggers that may influence glioma biology through rewiring immune surveillance. Allergic signals point to new biomarkers that may identify groups at higher risk of developing cancer, aid patient stratification and help monitor treatment and clinical outcomes. Allergic mediators such as histamine and IgE levels are emerging biomarkers that can inform cancer risk and lead to clinical interventions that improve outcomes. Emerging cancer immunotherapies, such as tumour antigen-specific IgEs, an evolving therapy class, are and will continue to be inspired by understanding allergic immune response mechanisms. Assays, including the Basophil Activation Test developed for monitoring and managing allergic reactions, are translated to the oncology clinic to evaluate hypersensitivity to anti-cancer therapeutics. Allergy research brings fundamental benefits for oncology through understanding and harnessing allergic and cancer-associated mechanisms in AllergoOncology for patient benefit.

Indexed as

HypersensitivityNeoplasmsAnimalsHumansImmunoglobulin EImmunotherapyTreatment OutcomeImmunoglobulin EAllergoOncologyallergycancerIgEimmune surveillanceimmunotherapy

Identifiers

PMID41672926
PMCPMC13065374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.