Evidence map›Paper›PMID 41672568›Full record

ArticleJournal of biophotonics2026

Characterizing Muscle Components in Intestinal Strictures Using Spectroscopic Photoacoustic Imaging.

Xiaorui Peng, Linyu Ni, Laura Johnson, Yaocai Huang, Wei Zhang, Xueding Wang, Peter D R Higgins, Guan Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaorui PengDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Linyu NiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Laura JohnsonDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Yaocai HuangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0009-0002-8597-4834
Wei ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Peter D R HigginsDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.
Guan XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Measuring Molecular and Mechanical Outcomes of Endoscopic Dilation of Fibrotic StricturesR01DK125687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Guan Xu · 2020 to 2026
$3.3M
Real time fine needle assessment of architectural heterogeneity in prostate cancerR37CA222829 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, GUAN · 2019 to 2025
$3.2M
NCI NIH HHS R37 CA222829NCI NIH HHS R37CA222829NIDDK NIH HHS R01 DK125687NIDDK NIH HHS R01DK125687
6 · The paper itself

Abstract

Inflammatory bowel disease is a chronic autoimmune disease that causes obstructive intestinal strictures, characterized by inflammation, fibrosis, and muscular hypertrophy. Accurately characterizing the stricture pathology for therapeutic planning remains challenging. In our previous study, using multispectral photoacoustic (PA) imaging, we investigated the feasibility of quantifying the hemoglobin and collagen components, corresponding to the inflammation and fibrosis, respectively, in animals in vivo and human subjects. In this study, we investigated resolving the myoglobin component that is associated with muscular hypertrophy with PA imaging. We quantified the hemoglobin and myoglobin ratios in a controlled phantom. We visualized the distribution of the tissue components in porcine tissue samples ex vivo. We also examined PA imaging in quantifying tissue components in human intestinal strictures and unstrictured margin ex vivo and in rabbits in vivo. The results show that PA imaging is a promising tool for characterizing the pathology of intestinal strictures.

Indexed as

IntestinesMusclesPhotoacoustic TechniquesAnimalsConstriction, PathologicHemoglobinsHumansPhantoms, ImagingRabbitsSpectrum AnalysisSwineHemoglobinsargon plasma coagulationinflammatory bowel diseasephotoacoustic/ultrasound imagingspectral unmixing

Identifiers

PMID41672568
PMCPMC12980817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.