Evidence map›Paper›PMID 41672525›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Eosinophilic Bronchiolitis Diagnosed by a Transbronchial Lung Cryobiopsy and Successfully Treated with Biologic Agents: A Report of Two Cases and Literature Review.

Katsuhiro Itogawa, Masako Amano, Daisuke Nakatani, Hiroki Ohta, Kenji Kusano, Tomohiro Oba, Rie Kawabe, Hideaki Yamakawa, Shintaro Sato, Keiichi Akasaka and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Katsuhiro ItogawaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Masako AmanoDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Daisuke NakataniDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Hiroki OhtaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Kenji KusanoDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Tomohiro ObaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Rie KawabeDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Hideaki YamakawaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Shintaro SatoDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Keiichi AkasakaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.
Akiko AdachiDepartment of Diagnostic Pathology, Saitama Red Cross Hospital, Japan.
Tamiko TakemuraDepartment of Pathology, Kanagawa Cardiovascular and Respiratory Center, Japan.
Hidekazu MatsushimaDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic bronchiolitis (EB) is a rare airway disease characterized by eosinophilic bronchiolar inflammation. We herein report two cases of EB diagnosed by a transbronchial lung cryobiopsy (TBLC), a less invasive diagnostic procedure than a surgical biopsy. Two patients with a history of refractory asthma responded to treatment with oral corticosteroids and biologic agents. To our knowledge, these are among the first reported cases of EB that were successfully managed with dupilumab and benralizumab. These cases underscore the diagnostic utility of TBLCs and suggest the potential use of biologic agents as corticosteroid-sparing options for EB.

Indexed as

Antibodies, Monoclonal, HumanizedBronchiolitisPulmonary EosinophiliaBiopsyBronchoscopyCryosurgeryFemaleHumansLungMaleMiddle AgedTreatment OutcomeAntibodies, Monoclonal, Humanizedbenralizumabdupilumabasthmabenralizumabbiologic agentcryobiopsydupilumabeosinophilic bronchiolitis

Identifiers

PMID41672525
PMCPMC13668778

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.