Evidence map›Paper›PMID 41672248›Full record

ArticleKidney international2026

Podocyte-derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis.

Liping Yu, Ubong S Ekperikpe, Hunter W Korsmo, Serena Zhao, Zhengzi Yi, Jonathan Haydak, Sean Lefferts, Kristin Meliambro, Kirk N Campbell, Evren U Azeloglu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Liping YuBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ubong S EkperikpeBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hunter W KorsmoBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Serena ZhaoBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Zhengzi YiBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jonathan HaydakBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sean LeffertsBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kristin MeliambroBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kirk N CampbellBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Evren U AzelogluBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Donald E KohanDivision of Nephrology, University of Utah Health, Salt Lake City, Utah, USA.
Phillip J McCownDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Abhijit S NaikDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Edgar A OttoMichigan Kidney Translational Medicine Center, Ann Arbor, Michigan, USA.
Börje HaraldssonInstitute of Neuroscience & Physiology, University of Gothenburg, Gothenburg, Sweden.
Weijia ZhangBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ilse S DaehnBarbara T. Murphy Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: ilse.daenhn@mssm.edu.

Funding

Glomerular Cell-Cell Crosstalk and InjuryR01DK097253 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAEHN, ILSE SOFIA · 2013 to 2025
$7.3M
Genetic risk and molecular characterization of Diabetic Kidney DiseaseR01DK139395 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ilse Sofia Daehn · 2024 to 2026
$1.0M
NIDDK NIH HHS R01 DK097253NIDDK NIH HHS R01 DK139395
6 · The paper itself

Abstract

introductionIncreased endothelin-1 (ET1) and endothelin receptor A (ET

methodsTo examine this, we developed mouse lines with endothelial cell-targeted and conditional deletion of ET

resultsThe absence of endothelial ET

conclusionsOur studies provide in vivo evidence that crosstalk of podocyte-derived ET1 with activation of GEC ET

Indexed as

Endothelial CellsEndothelin-1Glomerulosclerosis, Focal SegmentalKidney GlomerulusPodocytesReceptor, Endothelin AAlbuminuriaAnimalsDisease Models, AnimalDoxorubicinHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, KnockoutDoxorubicinEndothelin-1Intracellular Signaling Peptides and ProteinsMembrane ProteinsReceptor, Endothelin Acell crosstalkendothelin-1endothelin receptor Afocal segmental glomerulosclerosisglomerular endothelial cellspodocytes

Identifiers

PMID41672248
PMCPMC13631971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.