Evidence map›Paper›PMID 41672063›Full record

ArticleCell reports. Medicine2026

The Ca

Hongchen Zhang, Lijun Ma, Zheming Yue, Chuanhao Lu, Li Wang, Min Zhang, Jia Yong, Yuan Feng, Shiquan Wang, Hongjie Wang and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hongchen ZhangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Lijun MaDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Xi'an Medical University, Xi'an 710068, China.
Zheming YueDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; 3201 Hospital, Hanzhong 723000, China.
Chuanhao LuDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Li WangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Min ZhangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Jia YongDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Yuan FengDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710000, China.
Shiquan WangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Hongjie WangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Lu CheDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Yanghong BaiDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Northwest University, Xi'an 710069, China.
Weihao LvDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Zhibiao WangThe Fourth Military Medical University, Xi'an 710032, China.
Liang LiDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Juan WangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Yang YuDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Lei ZhangDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Qichao HuangDepartment of Physiology and Pathophysiology, The Fourth Military Medical University, Xi'an 710032, China.
Shuhui DaiDepartment of Neurosurgery, Xijing 986 Hospital, The Fourth Military Medical University, Xi'an 710000, China; National Translational Science Center for Molecular Medicine and Department of Cell Biology, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: daish_neuo@fmmu.edu.cn.
Xia LiDepartment of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: lixia_fmmu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) often has a poor prognosis, necessitating the exploration of effective therapeutic targets. Stromal interaction molecule 1 (STIM1) is a crucial regulator of cellular calcium homeostasis, but its specific role in ICH remains unclear. This study finds consistent elevation of STIM1 in neurons after ICH, with increased plasma levels in patients correlating with poor prognosis. Neuronal knockout of STIM1 in mice improves brain tissue damage and neurological injury. Mechanistically, STIM1 exacerbates neuronal injury primarily by promoting ferroptosis. Importantly, in addition to regulating calcium signaling pathways, STIM1 directly regulates iron homeostasis through its interaction with transferrin receptor 1 (TFR1) to promote ferroptosis. Finally, through virtual screening, S-IN-1 is identified as an inhibitor targeting STIM1-TFR1 interaction, protecting against neuronal ferroptosis and brain injury. These findings confirm the molecular function of STIM1 in regulating iron homeostasis, providing valuable insights and promising targets for ICH treatment.

Indexed as

Brain InjuriesCalciumCerebral HemorrhageFerroptosisIronNeuronsStromal Interaction Molecule 1AnimalsAntigens, CDCalcium SignalingHomeostasisHumansMaleMiceMice, Inbred C57BLMice, KnockoutAntigens, CDCalciumIronNeoplasm ProteinsReceptors, TransferrinSTIM1 protein, humanStim1 protein, mouseStromal Interaction Molecule 1ferroptosisintracerebral hemorrhageiron homeostasisneuronSTIM1TFR1

Identifiers

PMID41672063
PMCPMC12923954

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.