Evidence map›Paper›PMID 41671397›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Ufmylation-Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN-Mediated Adipocyte Lipogenesis.

Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yin LiShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tangjun ZhouShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao YangShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kewei RongShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiankun CaoShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei ShiShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin WangShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hongjin WanShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei CuiShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kexin LiuShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tong XingShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hang ZhangShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen ZhaoShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tingxian GuoShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peixiang MaShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie ZhaoShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-1000-5641
An QinShanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Clinical Research Plan of SHDC SHDC2023CRT008National Natural Science Foundation of China 82130073National Natural Science Foundation of China 82202737National Natural Science Foundation of China 82302722National Natural Science Foundation of China 82372429National Natural Science Foundation of China 82372430National Natural Science Foundation of China 92068102Science and Technology Commission of Shanghai Municipality 23ZR1437600Science and Technology Commission of Shanghai Municipality 24141901300Science and Technology Commission of Shanghai Municipality 24410710600Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal SystemShanghai Leading Talents Program in 2020
6 · The paper itself

Abstract

Fatty acid synthase (FASN) is a central regulator of obesity through de novo lipogenesis (DNL), undergoes precise control via the ubiquitin-proteasome system, yet its obesity-related post-translational modifications remain unclear. Our clinical investigation of human adipose tissue (n = 23) demonstrated elevated FASN protein in overweight individuals, mirroring high-fat diet (HFD) mouse models. However, transcriptomic analysis of 770 GEO samples paradoxically revealed inverse correlation between FASN mRNA and BMI. Mechanistically, we identified DDRGK1 as a UFMylation effector that stabilizes FASN by competitively inhibiting ubiquitination. Genetic disruption of this pathway in Ddrgk1

Indexed as

AdipocytesFatty Acid Synthase, Type ILipogenesisObesityAnimalsDiet, High-FatHumansMaleMiceProteinsUbiquitinationFASN protein, humanFasn protein, mouseFatty Acid Synthase, Type IProteinsUFM1 protein, humanDDRGK1de novo lipogenesisFASNUFMylation

Identifiers

PMID41671397
PMCPMC13073236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.