Evidence map›Paper›PMID 41671376›Full record

ArticleScience advances2026

Circular RNA

Ying Cai, Zhongyu Zheng, Haoyu Xu, Yao Zhu, José C Zepeda, Brad A Grueter, Xiaojie Wang, Taeyun Ku, Yangyang Duan, Hayley Wing Sum Tsang and 6 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ying CaiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-8275-9584
Zhongyu ZhengSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Haoyu XuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0009-0007-2106-1151
Yao ZhuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
José C ZepedaDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-8045-4883
Brad A GrueterDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-4224-3866
Xiaojie WangDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.
Taeyun KuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID 0000-0001-9447-7579
Yangyang DuanDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID 0000-0002-0823-6574
Hayley Wing Sum TsangDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID 0009-0000-3742-7719
Wing-Yu FuDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Amy Kit Yu FuDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID 0000-0003-4085-6201
Nikolaos MelliosCircular Genomics Inc., Albuquerque, NM, USA.
Hovy Ho-Wai WongSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0003-3317-478X
Kwok-On LaiDepartment of Neuroscience, City University of Hong Kong, Hong Kong, China.ORCID 0000-0002-4069-054X
Jacque Pak Kan IpSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0003-4545-8261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs are backspliced, closed-loop RNAs previously believed to be noncoding by-products formed during transcription. Increasing evidence suggests that circular RNAs have crucial functions in the brain, such as regulating neuronal transmission and synaptic plasticity. However, the specific molecular mechanisms by which circular RNAs function remain largely unexplored. Here, we investigated how

Indexed as

DendritesHippocampusRibonucleoproteinsRNARNA, CircularSynapsesAnimalsDendritic SpinesKinesinsMemoryNeuronal PlasticityRNA, MessengerKinesinsRibonucleoproteinsRNARNA, CircularRNA, Messenger

Identifiers

PMID41671376
PMCPMC12893322

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.