Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
28 authors.
Mitchell J CohenDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1402-5869
Christopher B EricksonDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-8116-7221
Ian S LacroixDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-4859-7024
Margot DebotDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9947-2520
Sanchayita SenDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Terry R SchaidDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-7183-0771
Lauren T GallagherDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-4381-8481
William M HallasDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Otto N ThielenDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-7703-1751
Alexis L CralleyDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Benjamin W StockerDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-3736-222X
Benjamin J RamserDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ava MokhtariDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-0683-2513
Huma BaigDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Christopher SubletteDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-0286-4502
Franklyn IheagwamDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-8487-4052
Alyssa Caldwell-McGeeDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0006-5944-7458
Jamie ColeDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0004-9837-9115
Kelly NashDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Marissa PokharelDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-6566-1817
Jessica C CardenasDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Anirban BanerjeeDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1690-2618
Ernest E MooreDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-0419-4848
Christopher C SillimanDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1498-1933
Alan HubbardDepartment of Biostatistics, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3769-0127
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-2258-6490
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-5054-838X
Funding
Trauma Reprograms CellsP50GM049222 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI BANERJEE, ANIRBAN · 1993 to 2017
$26.1M
Resuscitation Strategies for Achieving Thrombo-inflammatory HomeostasisRM1GM131968 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI COHEN, MITCHELL, D'ALESSANDRO, ANGELO · 2019 to 2023
$11.3M
Mechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1M
Endothelial regulation of inflammation in trauma and hemorrhagic shockR35GM146859 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jessica Cardenas · 2022 to 2026
$1.9M
The role of the protein C system in trauma induced coagulopathy and thromboinflammation: mechanisms and targeted therapy.R01HL182062 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, Laurent Olivier Mosnier · 2025 to 2026
Understanding the complexity of trauma-induced thromboinflammation necessitates data-driven approaches. We hypothesized that longitudinal plasma profiling could reveal underlying differences in patients with injury who present with similar clinical characteristics but ultimately have different outcomes. Here, we performed multiomic analyses of longitudinal plasma samples from a clinical trial of patients with traumatic injury to identify molecular endotypes and trajectories that were associated with patient outcomes. The pathophysiologic states of patients with trauma were defined by the longitudinal proteomic and metabolomic plasma profiles from a diverse cohort. Then, patients were endotyped according to their longitudinal trajectories through trauma omic states, and injury patterns and outcomes were compared. We identified endotypes associated with divergent clinical outcomes despite similar injury patterns at presentation. Organ failure and time spent in the intensive care unit (ICU) were predicted with high accuracy using omic markers. Patients who presented with evidence of elevated proteasome activation, catabolism, and superoxide formation were vulnerable to heart failure, lung failure, and acute lung injury, respectively. In addition, omic markers of increased hypoxia, RBC lysis, and hydrolase activity better fit mortality and ICU time compared with injury covariates, while providing biological insight. Injury and outcome patterns persisted in a validation trauma cohort after endotype assignment at a single, early time point. These data align with the understanding that patients with trauma may experience markedly different biological responses and outcomes despite similar clinical presentations. We suggest that mapping patient trajectories through biological injury states could provide a framework for personalized patient treatment after trauma.
Indexed as
InflammationThrombosisWounds and InjuriesAdultBiomarkersFemaleHumansIntensive Care UnitsLongitudinal StudiesMaleMetabolomicsMiddle AgedMultiomicsProteomicsBiomarkers
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma. · full record | OpenQuestion