Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Nalini R RaoDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-0913-5983
Ivan Santiago-MarreroDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-0378-3261
Olivia DeGulisDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0009-0002-3621-7343
Toshihiro NomuraDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0001-8786-831X
Kritika GoyalDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0001-6603-4981
SeungEun LeeDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0009-0001-5358-5482
Timothy J HarkDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Justin C DynesDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Emily X DexterDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0009-0004-4322-1222
Maciej DulewiczDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.ORCID 0000-0002-7149-017X
Junyue GeDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.
Arun UpadhyayDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Eugenio F FornasieroDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0001-7643-4962
Robert VassarDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-1358-504X
Jörg HanriederDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, 405 30 Mölndal, Sweden.ORCID 0000-0001-6059-198X
Anis ContractorDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-5131-2536
Jeffrey N SavasDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-8173-5580
Funding
TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Understanding Amyloid Pathology - Multiomic Activity Imaging of Plaque Formation Dynamics (AmyMAP)R01AG078796 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jeffrey Nicholas Savas · 2022 to 2026
$2.7M
Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration HubS10OD032464 · OD · NORTHWESTERN UNIVERSITY · PI SAVAS, JEFFREY NICHOLAS · 2023 to 2023
$1.3M
Insights into Amyloid Pathogenicity DynamicsR21AG080705 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HANRIEDER, JORG, SAVAS, JEFFREY NICHOLAS · 2023 to 2024
Amyloid-β (Aβ) peptides are a defining feature of Alzheimer's disease (AD). These peptides are produced by the proteolytic processing of the amyloid precursor protein (APP), which can occur through the synaptic vesicle (SV) cycle. However, how amyloidogenic APP processing alters SV composition and presynaptic function is poorly understood. Using App knock-in mouse models of amyloid pathology, we found that proteins with impaired degradation accumulate at presynaptic sites together with Aβ
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models. · full record | OpenQuestion